A Meta-analysis of the efficacy of integrative medicine on non-alcoholic fatty liver disease
Objective:To systematically evaluate the efficacy of integrative medicine on non-alcoholic fatty liver disease,and provide evidence for rational clinical application.Methods:The time was limited to January 1,2018 to January 1,2022.By searching PubMed,Cochrane Library,Embase,Wanfang Database,CNKI,VIP database and CBM database,we selected the literature on the treatment of non-alcoholic fatty liver with integrative medicine,and extracted the RCTs for the treatment of non-alcoholic fatty liver.RCTs that meet the criteria were selected for quality evaluation,and Meta-analysis was carried out using RevMan 5.3 software.RR was used as the effect amount for counting data,MD or SMD was used for measurement data,and 95%CI was calculated for each effect amount.The I2 statistic and P value were used to assess the heterogeneity of the included literature,and if P>0.05 and I2≤50%,fixed effects were used for analysis,otherwise random effects were used for Meta-analysis.Results:A total of 363 articles were retrieved,and 34 articles were finally included,involving a total of 2 973 patients.There were 1 489 cases in the experimental group and 1 484 cases in the control group.Compared with the control group,the experimental group showed higher total efficiency[RR=1.23,95%CI(1.19,1.27),P<0.000 01],ALT[MD=-13.17,95%CI(-15.25,-11.05),P<0.000 01],AST[MD=-11.22,95%CI(-12.80,-9.64),P<0.000 01],TG[MD=-0.72,95%CI(-0.86,-0.58),P<0.000 01],and TC[MD=-0.96,95%CI(-1.13,-0.80),P<0.000 01],and the difference was statistically significant.While the differences in BMI[MD=-3.13,95%CI(-8.06,-1.81),P=0.21],the difference was not statistically significant.Conclusion:In the treatment of non-alcoholic fatty liver disease,the integrative medicines is superior to western medicines alone and can significantly improve lipid metabolism in non-alcoholic fatty liver disease,improve clinical efficacy and have a clear safety profile,but better quality RTCs are needed to confirm this.
The integrative medicineNon-alcoholic fatty liver diseaseRandomized controlled trialMeta-analysis
万方数据
维普
