首页|丹藤通脉方治疗2型糖尿病周围神经病变患者的临床疗效观察

丹藤通脉方治疗2型糖尿病周围神经病变患者的临床疗效观察

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目的:探讨丹藤通脉方用于治疗 2 型糖尿病周围神经病变的临床疗效.方法:选择 2019 年 1 月-2021 年 12 月在南京中医药大学附属徐州市中医院内分泌科住院治疗的 2 型糖尿病周围神经病变患者 60 例;采用随机法将上述患者分为观察组和对照组(每组 30 例);对照组给予基础治疗联合甲钴胺治疗,观察组在对照组治疗基础上给予联合丹藤通脉方治疗.治疗周期共 12 周,对比两组疗效.结果:治疗后组间效果比较,观察组患者的总有效率高于对照组(P<0.05).多伦多临床评分系统(Troronto Clinical Scoring System,TCSS)评分低于对照组(P<0.05);空腹血糖(Glucose,GLU)、餐后 2小时血糖(2-hour Postprandial Blood Glucose,2 h PG)、糖化血红蛋白(Hemoglobin A1c,HbA1 c)水平低于对照组(P<0.05);总胆固醇(Total Cholesterol,TC)、三酰甘油(Triglycerides,TG)、低密度脂蛋白(Low Density Lipoprotein,LDL)水平低于对照组(P<0.05);右腓神经及正中神经的运动神经传导速度(Sensory Nerve Conduction Velocity,SNCV)和感觉神经传导速度(Motor Nerve Conduction Velocity,MNCV)高于对照组(P<0.05).与治疗前比较,观察组和对照组治疗后的TCSS、GLU、2 h PG、HbA1 c水平及TC、TG、LDL水平均降低(P<0.05),右腓神经及正中神经的MNCV和SNCV均升高(P<0.05).结论:丹藤通脉方治疗糖尿病周围神经病变患者疗效确切,安全性良好,值得进一步推广.
Clinical observation on the Danteng Tongmai prescription on peripheral neuropathy of type 2 diabetes mellitus
Objective:To investigate the clinical effect of the Danteng Tongmai prescription(丹藤通脉方)in the treatment of type 2 diabetic peripheral neuropathy(DPN).Methods:A total of 60 patients with type 2 DPN hospitalized in the Endocrinology Department of Xuzhou Hospital of Traditional Chinese Medicine from January 2019 to December 2021 were selected,and randomly divided into the observation group and the control group,with 30 cases in each group.The control group was treated with basic treatment combined with mecobalamin,and the observation group was treated with the Danteng Tongmai prescription on the basis of the treatment of the control group.The treatment period was 12 weeks,and the curative effects in the two groups were compared.Results:Comparison between groups after treatment,the total effective rate in observation group was higher than that in control group(P<0.05).TCSS was lower than that in the control group(P<0.05).The levels of GLU,2 h PG and HbA1 c were lower than those in the control group(P<0.05).The levels of TC,TG and LDL were lower than those in the control group(P<0.05).SNCV and MNCV of right peroneal nerve and median nerve were higher than those in the control group(P<0.05).Compared with before treatment,the levels of TCSS,GLU,2 h PG,HbA1 c,TC,TG and LDL in the observation group and the control group after treatment were decreased(P<0.05),and the MNCV and SNCV of the right peroneal nerve and median nerve were increased(P<0.05).Conclusion:The Danteng Tongmai prescription is effective and safe in the treatment of diabetic peripheral neuropathy,which is worthy of further promotion.

The Danteng Tongmai prescriptionType 2 diabetesDiabetic peripheral neuropathy

张萍、王智明、隋淼、周传礼、李晨

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南京中医药大学附属徐州市中医院,江苏 徐州,221000

丹藤通脉方 2型糖尿病 糖尿病周围神经病变

江苏省中医药科技发展计划项目

MS2021048

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(2)
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