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绝经后骨质疏松症的中医病机认识及治疗进展

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绝经后骨质疏松症(Postmenopausal Osteoporosis,PMOP)是临床常见的以全身骨骼疼痛、易于并发骨折为特征的全身代谢性骨骼疾病,具有发病率高、致残率及致死率极高、医疗费用高及治疗依从性低、诊断率低、治疗率低等特点,后期通常并发腰椎、腕关节及髋部骨折等,特别是其并发的髋部骨折被称为"人生最后一次骨折".随着近年来社会人口老龄化速率加快,其发病率亦显著增加,严重影响患者生活质量及生活水平,消耗着国家有限的医疗资源,关于其防治已成为全球关注的公共卫生健康问题.中医将其归属于"骨痿""骨痹""骨枯"等范畴,认为其发病与肾精不足,肝阴血虚,脾胃虚弱,瘀血阻络或少阳经气阻塞导致脏腑气血不充,少阳经气不利紧密相关.当前其治疗以西药治疗为主,在取得临床疗效的同时亦显示出明显的不良反应.随着近年来中医药防治PMOP研究的不断深入,中医药治疗骨质疏松日渐得到重视,大量研究及临床用药经验得出,中医药治疗能够在取得临床疗效的同时有效地规避西药治疗带来的不良反应,显示出良好的临床效果及独特的优势.文章从中医对PMOP病名及病因病机的认识、传统中药或复方治疗及非药物治疗的临床效果方面做一综述,以期为PMOP的临床防治提供参考借鉴.
A review on the TCM pathogenesis and treatment of postmenopausal osteoporosis
Postmenopausal osteoporosis(PMOP)is a common clinical systemic metabolic bone disease characterized by systemic bone pain and susceptibility to fracture.It is characterized by high morbidity,extremely high disability rate and high mortality rate,high medical cost,low treatment dependence,low diagnosis rate and treatment rate.Later,it is usually complicated by lumbar spine,wrist and hip fractures.In particular,the concurrent hip fracture is known as"the last fracture of life".With the acceleration of the aging rate of the social population in recent years,the incidence has also increased significantly,seriously affecting the quality of life and living standards of patients,consuming the limited medical resources of the country,and its prevention and treatment has become a global public health concern.Traditional Chinese medicine classifies it into"Bone flaccidity","Bone paralysis","Bone withering"and other categories,and believes that its onset is closely related to the deficiency of kidney essence,liver Yin(阴)blood deficiency,spleen and stomach weakness,blood stasis blocking collaterality or Shaoyang(少阳)channel Qi(气)obstruction leading to zang-fu organs(脏腑)Qi and blood insufficiency,unfavorable Shaoyang channel Qi.At present,it is mainly treated with Western medicine,which has obvious adverse reactions while obtaining clinical efficacy.With the deepening of research on the prevention and treatment of PMOP in traditional Chinese medicine in recent years,TCM treatment of osteoporosis has received increasing attention.A large number of studies and clinical drug application experience have shown that traditional Chinese medicine can achieve clinical efficacy while effectively avoiding the adverse reactions caused by Western medicine treatment,showing good clinical effects and unique advantages.This article summarizes the recognition of the name,etiology and pathogenesis of PMOP,and the clinical effects of Chinese medicinal materials or compound treatment and non-drug treatment,in order to provide references for the clinical prevention and treatment of PMOP.

Postmenopausal osteoporosisTCMPathogenesisTreatmentProgress

贾元霞、郭雪梅、傅巧霞、康妍丽、李建国

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甘肃省中医院,甘肃 兰州,730030

西北民族大学附属医院,甘肃 兰州,730000

甘肃省第二人民医院,甘肃 兰州,730000

绝经后骨质疏松 中医 病机 治疗 进展

中央高校基本科研业务费专项兰州市科技计划国家自然科学基金地区科学基金国家自然科学基金地区科学基金

319202100412022-3-98186086482160911

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(3)
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