A study on the therapeutic mechanism of Xiangjiapi on rheumatoid arthritis based on network pharmacology and molecular docking technique
Objective:A network pharmacological approach and molecular docking technique were used to predictively investigate whether Xiangjiapi(Cortex Periplocae)has a therapeutic mechanism of action in treating rheumatoid arthritis.Methods:The database and literature were used to identify the active ingredients and effective targets of Xiangjiapi,rheumatoid arthritis-related targets,and intersection targets of Xiangjiapi and rheumatoid arthritis,and the network pharmacology method was used to construct the correlation map between TCM and diseases and PPI network map,and GO and KEGG analyses were carried out,and the top-ranked components and targets in the topological parameter were screened out for molecular docking to validate the docking and binding degree.Results:A total of 24 active ingredients of Xiangjiapi were screened out by network pharmacology,and 8 potential core components were molecularly docked with 9 potential core targets,and it was found that the binding energies were all≤-5 kcal/mol,and most of them were<-7 kcal/mol.The main GO enrichment involved the extracellular matrix disassembly,reactive oxygen species metabolism,and the regulation of inflammation response.The main pathways involved TNF signaling pathway,AGE-RAGE signaling pathway,regulation of TRP channels by inflammatory mediators,IL-17 signaling pathway and other pathways.Conclusion:This study preliminarily reveals the intervention mechanism of Xiangjiapi in treating rheumatoid arthritis,which has the characteristics of multiple components,multiple targets,and multiple pathways,and may play a therapeutic role.It providing scientific reference for its clinical research.
万方数据
维普
