A Meta-analysis of cervus and cucumis polypeptide injection combined with conventional western medicine in the treatment of rheumatoid arthritis
Objective:To systematically evaluate the efficacy of cervus and cucumis polypeptide injection combined with conventional western medicine in the treatment of rheumatoid arthritis,and to provide an evidence-based basis for clinical treatment.Methods:PubMed,The Cochrane Library,Embase,Web of Science,CNKI,Wanfang,VIP,SinoMed databases were searched by computer to collect randomized controlled trials of cervus and cucumis polypeptide injection combined with conventional Western medicine in the treatment of rheumatoid arthritis,and the search period was from the construction time of each database to January 5,2023,and RevMan 5.3 was used for bias assessment and Meta-analysis after literature screening and data extraction by two members.Results:A total of 14 articles with 1285 patients were included.Meta-analysis showed that the experimental group had a joint VAS score[MD=-2.58,95%CI(-5.02,-0.13)],number of joint swelling[MD=-2.08,95%CI(-3.25,-0.91)],grip strength[MD=1.63,95%CI(0.31,2.96)],duration of morning stiffness[MD=-0.61,95%CI(-1.05,-0.18)],erythrocyte sedimentation rate[MD=-2.15,95%CI(-3.72,-0.58)],C-reactive protein[MD=-1.42,95%CI(-2.74,-0.11)],rheumatoid factor[MD=-4.39,95%CI(-7.95,-0.82)]were better than the control group with fewer adverse reactions,and the difference was statistically significant(P<0.05).Conclusion:Cervus and cucumis polypeptide injection combined with conventional western medicine has good efficacy on rheumatoid arthritis,which is worthy of clinical promotion and application.
Cervus and cucumis polypeptide injectionRheumatoid arthritisClinical efficacyMeta-analysis
万方数据
维普
