Mechanism analysis of treating angina pectoris of coronary heart disease with Xiebai based on network pharmacology
Objective:From the perspective of network pharmacology,the mechanism of Xiebai(Bulbus Allii Macrostemonis)in treating coronary heart disease angina pectoris was studied to provide reference for new drug development and the clinical application of classic prescriptions.Methods:The main compound components and corresponding targets in Xiebai were acquired through TCMSP database.The main targets of coronary heart disease angina pectoris were obtained through databases such as DisGeNET and GeneCards.The intersection targets between disease and drug were taken,and then the protein-protein interaction network diagram of Xiebai on the exact targets of angina pectoris was established through the STRING platform,and the potential protein functional modules were excavated.The data was imported into DAVID database for gene ontology(GO)functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis.Results:A total of 11 active chemical components and 876 effective targets were screened out in Xiebai,and 4 282 disease targets were obtained in angina pectoris,and 24 key targets of Xiebai in treating coronary heart disease angina pectoris were found.The results showed that the targets AKT1,PPARG,CASP3,and PTGS2 are well associated with other proteins,indicating that these targets are key targets for Xiebai to treat angina pectoris.GO analysis revealed 11 entries most relevant to the disease,which may be associated with oxidation stress,positive regulation of apoptosis,cytoplasm,ATP binding,coactivator binding,and sequence-specific DNA binding.KEGG pathway enrichment analysis revealed 6 pathways most closely related to the disease,mainly including lipid metabolism and atherosclerosis,PPAR,MAPK,IL-17,HIF-1 and TNF signaling pathways.Conclusion:This study shows that Xiebai granules in the treatment of coronary heart disease angina pectoris has characteristics such as multi-components,multi-targets,and multi-pathways,which can lay a foundation for the future clinical utilization and development of Xiebai.
Network pharmacologyXeibaiAngina pectoris of coronary heart diseaseMechanism of action
万方数据
维普
