Research progress on the mechanism of TCM medicine for treating chronic heart failure with supplementing Qi and activating blood
Chronic Heart Failure(CHF)is a progressive and debilitating disease with high mortality and rehospitalization rate.It has been reported that the large and increasing number of CHF patients has become a serious social and public health problem.In recent years,although modern medicine has made continuous improvements in drug therapy,but they still cannot overcome the deficiencies such as high fatality rate and obvious toxic side effects.Chinese medicine believes that CHF disease is located in the heart,deficiency of heart and Qi(气),weakness of pushing,blood stasis and dysfunction of the Five-Zang(五脏)organs are the main pathogenesis of CHF.Therefore,supplementing Qi for activating blood circulation is an effective method to treat CHF.Supplementing Qi for activating blood circulation medicine(drugs for supplementing Qi and activating blood circulation)is a kind of TCM medicine with the main efficacy of tonifying deficiency and strengthening the weak,dredging blood vessels,and mainly treating Qi deficiency and blood stasis syndrome.Its representative medicines such as Renshen(Radix Ginseng),Huangqi(Radix Astragali),Danshen(Radix et Rhizoma Salviae Miltiorrhizae),Danggui(Radix Angelicae Sinensis),Chuanxiong(Rhizoma Chuanxiong)are commonly used in the treatment of heart-Qi deficiency syndrome of CHF.Renshen and Huangqi benefit Qi and strengthen heart,and cooperate with Danggui and Chuanxiong to promote blood stasis and relieve deficiency of heart Qi,shortness of breath and exhaustion,and bad blood flow.Many studies have shown that TCM for supplementing Qi and promoting blood circulation has the characteristics of multiple components,multiple approaches and multiple targets,showing unique advantages in improving symptoms and quality of life in patients with heart failure.However,its mechanism of action has not been fully clarified,which is an important issue to be solved urgently.Recent studies have found that its mechanism of action is related to hemodynamics,neuroendocrine system,endothelial injury,immune regulation,inflammatory factors,oxidative stress,myocardial energy metabolism,ventricular remodeling,autophagy and apoptosis.Therefore,the purpose of this paper is to summarize the mechanism of improving heart function by Supplementing Qi for activating blood circulation herbs,in order to provide new ideas for the treatment of CHF syndrome of Qi deficiency and blood stasis.
Supplementing Qi for activating blood circulationChronic heart failureMechanismResearch progress
万方数据
维普
