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浅析"亢害承制"与原发性肝癌

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原发性肝癌作为最常见的恶性肿瘤之一,其发病率呈明显的地域特点,以东亚、东南亚及非洲较高,其病死率位居所有恶性肿瘤中的第三位,严重威胁人类的生命健康.其发病原因与肝炎病毒感染、黄曲霉毒素、饮酒、饮用水污染等因素相关.抑癌基因失活及原癌基因的激活与肝癌细胞增殖转移有关."亢害承制"理论源于《黄帝内经》,该理论以天人相应和整体观为基础."亢害承制"理论认为原发性肝癌发病过程中,邪毒六淫、情志过极、饮食失度等亢而为害,正气亏虚、脏腑失调则是原发性肝癌发病承制失稳的内在条件."亢害承制"理论不仅总结了自然界中的自我稳态的调节机制,也以此提出人体内环境及各脏腑之间的自我调节机制,以及各种疾病的发生发展的内在原因.在此理论基础上,原发性肝癌的治疗上应遵循"大毒平其亢、扶正固其承制、顺其承制以防复"的原则."亢害承制"理论在原发性肝癌的发病及进展过程中贯穿始终,灵活运用"亢害承制"思想指导临床实践,以大毒之药平其亢气,扶正补虚固其承制不及,其为原发性肝癌的中医治疗方案提供新思路,是提高原发性肝癌临床疗效和患者生活质量的重要途径,这不仅丰富了原发性肝癌的中医治疗理论与方法,更是对中医药治癌新模式的有益探索,值得临床进一步推广和应用.
A brief analysis of the relationship between the harmful hyperactivity and responding inhibition theory and primary hepatic carcinoma
Primary hepatic carcinoma is one of the most common malignant tumors.Its incidence has obvious regional characteristics,which is higher in East Asia,Southeast Asia and Africa,and its incidence rate ranks the third among all malignant tumors,seriously threatening human life and health,and its pathogenesis is related to hepatitis virus infection,aflatoxin,drinking,drinking water pollution and other factors.The inactivation of tumor suppressor genes and the activation of proto-oncogenes are related to the proliferation and metastasis of hepatocellular carcinoma cells.The harmful hyperactivity and responding inhibition theory originates from Huangdi Neijing(《黄帝内经》)and is based on correspondence between man and universe and holistic theories.The theory of harmful hyperactivity and responding inhibition holds that in the pathogenesis of primary liver cancer,six pathogens,excessive emotion and improper diet are the causes,while healthy Qi(气)deficiency and viscera imbalance are the internal causes.the harmful hyperactivity and responding inhibition theory not only summarizes the regulation mechanism of self-homeostasis in nature,but also puts forward the self-regulation mechanism of human internal environment and viscera and the internal causes of disease occurrence and development.On the basis of this theory,the treatment of primary hepatic carcinoma should follow the principle of stabilizing harmful hyperactivity with toxic traditional Chinese medicines,strengthening the body resistance to consolidate response inhibition,and continuing to consolidate in order to prevent and cure recurrence.Harmful hyperactivity and responding inhibition runs through the pathogenesis and progression of primary hepatic carcinoma,and flexibly uses this theory to guide clinical practice and provide new ideas for the TCM treatment of primary hepatic carcinoma.It is an important way to improve clinical efficacy and patients'quality of life,which not only enriches the theories and methods of traditional Chinese medicine in the treatment of primary hepatic carcinoma,but also is a beneficial exploration of the new mode of traditional Chinese medicine in the treatment of cancer,which is worthy of further clinical application and promotion.

Primary hepatic carcinomaHarmful hyperactivity and responding inhibitionGeneration-inhibition in five elementsSelf-healing

卢瑞枫、易良杰

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广州中医药大学,广东 广州,510000

广州中医药大学惠州医院(惠州市中医医院),广东 惠州,516000

原发性肝癌 亢害承制 五行生克 自愈

广东省中医药局科研项目

20231347

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(5)
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