A Meta-analysis of efficacy and safety of the Qingjin Huatan decoction plus the Maxing Shigan decoction on chronic obstructive pulmonary disease
Objective:To analyze the efficacy and safety of the Qingjin Huatan decoction(清金化痰汤)combined with the Maxing Shigan decoction(麻杏石甘汤)on chronic obstructive pulmonary disease by Meta-analysis.Methods:Randomized controlled trials on the clinical efficacy of the Qingjin Huatan decoction with the Maxing Shigan decoction on chronic obstructive pulmonary disease were searched using PubMed database,CNKI,etc.from the database of establishment to October 2022.The quality of the literature meeting the inclusion criteria was assessed based on the Cochrane Risk Bias Assessment Tool,and Meta-analysis was performed on these studies using RevMan 5.4 software.Results:Six clinical randomized controlled studies,with a total of 443 patients(with 221 patients in the experimental group and 222 patients in the control group),finally met the inclusion criteria.Compared with the control group(conventional application of western medical treatment),the Qingjin Huatan decoction with the Maxing Shigan decoction(the experimental group)significantly improved the overall efficiency[OR=6.64,95%CI(2.45,17.98),P<0.000 01],relieved the symptoms of cough,wheezing and croup[MD=-1.09,95%CI(-1.21,-0.97),P<0.000 01],[MD=-1.18,95%CI(-1.31,-1.06),P<0.000 01],[MD=-1.05,95%CI(-1.13,-0.97),P<0.000 01].FEV1 and FEV1%in the observation group were significantly improved[MD=0.44,95%CI(0.34,0.53),P<0.000 01][MD=5.48,95%CI(3.32,7.64),P<0.000 01].The treatment in the experimental group didn't increase the incidence of adverse reactions after treatment[RR=0.79,95%CI(0.43,1.45),P=0.45].Conclusion:The results showed that the Qingjin Huatan decoction plus the Maxing Shigan decoction could improve the clinical efficacy and clinical symptoms in the treatment of chronic obstructive pulmonary disease with high safety.
The Maxing Shigan decoctionThe Qingjin Huatan decoctionChronic obstructive pulmonary diseaseMeta-analysis
万方数据
维普
