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基于数据挖掘的中药治疗功能性消化不良的用药规律研究

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目的:分析探讨治疗功能性消化不良中药方剂的组方规律.方法:通过计算机检索中国知网数据库、万方数据库、维普全文期刊数据库等自建刊以来国内众多学者运用中医方剂治疗功能性消化不良的文献,运用古今医案云平台V2.2.3 系统集成的数据挖掘模块对处方中药物出现的频次、属性分析,聚类分析,关联分析及复杂网络分析.结果:最终纳入文献106 篇,包含 125 味中药,19 类中医证型.得出高频证型肝胃不和证、脾虚气滞证、脾胃虚弱证等,高频药物甘草、白术、柴胡、党参、半夏等,药性以温、平、微寒为主,药味以辛、苦、甘为主,归经以脾胃、肺肝为主,关联分析出 17 组高度关联的中药药对,聚类分析出 4 大类组方,复杂网络分析得出核心药物组合.结论:功能性消化不良以肝胃不和为主要病机,脾胃气虚是其发病的关键,病程日久气机不畅则酿生湿热、食积、痰浊等病理产物,故临床多以柴胡疏肝散为基础方加减化裁治疗功能性消化不良.
A study on the medication rule of treating functional dyspepsia in TCM based on data mining
Objective:To investigate the rule of TCM prescription for functional dyspepsia(FD).Methods:By searching CNKI,Wanfang,VIP,etc.from establishment of a database,literature on the treatment of FD in TCM was searched.By using the ancient and modern basis cloud platform V2.2.3 system,integration of the data mining module of prescription drugs in frequency,attribute analysis,clustering analysis,association analysis and complex network analysis were explored.Results:A total of 106 literatures were included,including 125 TCM and 19 TCM syndrome types.High-frequency syndrome types were incoordination between the liver and the stomach,spleen deficiency and Qi(气)stagnation,weakness of the spleen and stomach.High-frequency medicines were Gancao(Radix Glycyrrhizae),Baizhu(Rhizoma Atractylodis Macrocephalae),Chaihu(Radix Bupleuri),Dangshen(Radix Codonopsis),Banxia(Rhizoma Pinelliae),etc..Medicinal properties is given priority to with warm,flat,slightly chilly,taste is given priority to with sheen,bitter,sweet,belong to the is given priority to with spleen and stomach,lung,liver,correlation analysis of 17 highly associated set of medicine of Chinese medicine,clustering analysis the four categories of prescriptions,and core drug combinations were derived from complex network analysis.Conclusion:FD is mainly pathogenesis caused by liver and stomach disharmony,and spleen and stomach Qi deficiency is the key to its onset.The course of the disease is long,and the Qi is not smooth,resulting in pathological products such as dampness and heat,food accumulation,phlegm turbidity,etc.,so the clinical treatment of FD is mostly based on Chaihu Shugan San(柴胡疏肝散).

Functional dyspepsiaData miningMedication rule

赵毅、王雪妍

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湖北中医药大学,湖北 武汉,430065

功能性消化不良 数据挖掘 用药规律

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(5)
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