The value of combined detection of CEA,CA153 and CA125 in nipple discharge in the diagnosis of breast cancer
Objective:To investigate the clinical application value of the combined detection of carcinoembryonic antigen(CEA),carbohydrate antigen 153(CA153)and carbohydrate antigen 125(CA125)in the diagnosis of breast cancer.Methods:A total of 92 cases of breast invasive ductal carcinoma with nipple discharge(the breast cancer group)and 50 cases of breast ductal hyperplasia with nipple discharge(the benign control group)were collected as the research objects.The nipple discharge and serum CEA,CA153,CA125 levels in the two groups of patients were detected by electrochemiluminescence method.With pathological diagnosis as the gold standard,the value of nipple discharge CEA,CA153,CA125 joint detection in the diagnosis of breast cancer was statistically analyzed by four grid method.Results:The levels of CEA,CA153,CA125 in nipple discharge and serum in breast cancer group were significantly higher than those in benign control group,and the levels of CEA,CA153,CA125 in nipple discharge in breast cancer group were significantly higher than those of corresponding in the breast cancer group(all P<0.01).The expression levels of CEA,CA153,CA125 in nipple discharge of breast cancer patients were positively correlated with the corresponding serum expression levels(r=0.872,0.789,0.843),P<0.01.In the breast cancer group,the levels of CEA,CA153 and CA125 in nipple discharge were not significantly correlated with the patient's age and tumor site(P>0.05),but were significantly correlated with tumor size,differentiation degree,clinical stage,metastasis and recurrence(P<0.01).The levels of CEA,CA153 and CA125 in nipple discharge of patients with tumor diameter>2 cm,low differentiation,high staging,metastasis and recurrence were significantly higher than those of patients with tumor diameter≤2 cm,high differentiation,low staging,and no metastasis and recurrence.The sensitivity,accuracy and negative predictive value of the combined detection of CEA,CA153 and CA125 in nipple discharge in the diagnosis of breast cancer were significantly higher than those of single and serum combined detection(P<0.01),which were 94.57%(87/92),92.25%(131/142)and 89.80%(44/49)respectively.Conclusion:The combined detection of CEA,CA153 and CA125 in nipple discharge provides a new idea for the early diagnosis of breast cancer with nipple discharge,and significantly improves the diagnostic value of breast cancer.
万方数据
维普
