目的:随着超重或肥胖的2型糖尿病(Type 2 Diabetes Mellitus,T2DM)的患病群体越来越大,超重或肥胖的T2DM已给患者及其家庭、社会、国家构成了严重经济负担,通过控制体质量进而控制血糖是针对超重或肥胖的T2DM的重要治疗措施.本研究者所在团队创立的中医禁食疗法就是治疗超重或肥胖的T2DM的重要选择,中医禁食疗法通过5d的禁食结合中药内服及中医综合治疗方法来治疗超重或肥胖的T2DM患者,疗效明显,由于糖、脂类、蛋白质等物质的代谢与肝脏密切相关,在禁食期间,肝脏的代谢负荷会明显增加,肝功能在禁食期间的变化是本研究者所重点关注的方向,本研究的目的是从肝功能角度回顾性研究中医禁食疗法治疗T2DM的安全性与疗效.方法:从既往出院患者中筛选出46例T2DM患者,比较T2DM患者在进行中医禁食疗法治疗前后在空腹血糖、体质量、体质量指数(Body Mass Index,BMI)、肝功能指标(蛋白质代谢功能、胆红素代谢、血清酶)方面的变化情况.结果:46例T2DM患者,进行中医禁食疗法治疗后,在空腹血糖、体质量、体质量指数、总蛋白、球蛋白、γ-谷氨酰基转移酶、碱性磷酸酶、腺苷脱氨酶等方面与治疗前相比明显下降,在天冬氨酸氨基转移酶、总胆红素、直接胆红素、间接胆红素等方面相较于治疗前有上升趋势,而在白蛋白、丙氨酸氨基转移酶、胆碱酯酶、胆汁酸等方面相较于治疗前无显著性改变.结论:中医禁食疗法治疗T2DM安全有效.
Clinical study of traditional Chinese medicine fasting therapy in the treatment of type 2 diabetes mellitus from the perspective of liver function
Objective:With the increasing incidence of overweight or obese type 2 diabetes mellitus(T2DM),overweight or obese T2DM has posed a serious economic burden to patients and their families,society and country.Controlling blood glucose by controlling body mass is an important treatment measure for overweight or obese T2DM.The traditional Chinese medicine fasting therapy created by the team of the researchers is an important choice for the treatment of overweight or obese T2DM patients.The traditional Chinese medicine fasting therapy treats overweight or obese T2DM by 5-day fasting combined with oral administration of traditional Chinese medicine and comprehensive treatment of traditional Chinese medicine,with obvious curative effects.Since the metabolism of sugar,lipid,protein and other substances is closely related to the liver,the metabolic load of the liver will increase significantly during fasting,and the changes of liver function during fasting are the focus of this study.The objective of this study is to retrospectively study the safety and efficacy of traditional Chinese medicine fasting therapy in the treatment of T2DM from the perspective of liver function.Methods:A total of 46 eligible T2DM patients were selected from the discharged patients,and the changes of fasting blood glucose,body weight,body mass index,liver function indexes(protein metabolism,bilirubin metabolism,serum enzyme)before and after the treatment of traditional Chinese medicine fasting therapy were compared.Results:Among 46 T2DM patients,fasting blood glucose,body weight,body mass index,total protein,globulin,γ-glutamyltransferase,alkaline phosphatase,adenosine deaminase and other aspects were significantly decreased after treatment compared with those before treatment.The levels of aspartate aminotransferase,total bilirubin,direct bilirubin and indirect bilirubin were increased compared with those before treatment,while the levels of albumin,alanine aminotransferase,cholinesterase and bile acid had no significant changes compared with those before treatment.Conclusions:The traditional Chinese medicine fasting therapy is safe and effective in the treatment of T2DM.
Liver functionThe traditional Chinese medicine fasting therapyType 2 diabetes mellitusClinical study
万方数据
维普
