Discussion on the treatment of cancer-related fatigue based on the theory of weakness fatigue in Jin'gui Yaolue
Cancer-related fatigue(CRF)is a painful,persistent,and intense subjective feeling in patients during tumor treatment,which is not related to the patients'recent activity level,but is related to the tumor or the treatment of the tumor,which is difficult to be relieved by rest,and seriously interferes with daily life.CRF has a high incidence and a long duration,which runs through-out the whole process of occurrence,development,treatment and prognosis of tumor,and it is one of the most common complications of cancer.In some severe patients,CRF may lead to the interruption of tumor treatment,resulting in life-threatening serious consequences.Since Modern medicine has not fully clarified the pathogenesis of CRF,Western medicine has not yet developed effective drugs for its treatment,and more symptomatic supportive treatment such as central stimulants,corticosteroid hormones are mainly used.A number of studies have shown that such treatment is not effective,and there are many adverse effects of long-term use of central stimulants,cortico-steroid hormones.At present,there is no specific name for CRF in TCM.According to the comprehensive analysis of its etiology,patho-genesis and clinical manifestations,it is generally classified into the category of"weakness fatigue".The etiology and pathogenesis of the disease are complex,which may be closely related to the cancer toxicity accumulation injury,the six pathogenic factors invasion injury,drug poison injury,etc..The pathogenesis lies in the deficiency of Qi(气)and blood,Yin and Yang(阴阳),dysfunction of the zang-fu viscera(脏腑).In Jin'gui Yaolue(《金匮要略》)Chamber,ZHANG Ji elaborates the principles,methods,prescriptions and drugs for the treatment of weakness fatigue.Based on the theory of weakness fatigue in Jin'gui Yaolue,this paper discusses the treatment of CRF from four aspects:nourishing spleen and stomach and strengthening middle-energizer Qi,paying attention to pulse condition,harmonizing Yin and Yang,and reinforcing the healthy Qi and eliminating the pathogenic factors,etc.The article combines the theory of weakness fatigue with clinical practice to provide more references for the clinical treatment of CRF.
Cancer related-fatigueJin'gui YaolueWeakness fatigue
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