An analysis of TCM syndrome and cluster of 100 nasopharyngeal carcinoma patients with radiotherapy and chemotherapy
Objective:To explore the distribution characteristics of TCM syndrome and syndrome types during radiotherapy and chemotherapy of nasopharyngeal carcinoma,and to provide ideas for establishing TCM clinical syndrome differentiation and guiding TCM syndrome differentiation and treatment.Methods:The general conditions of 100 nasopharyngeal carcinoma patients with radiotherapy and chemotherapy were recorded.At the same time,the designed TCM syndrome questionnaire was used to collect four diagnosis data,and cluster analysis was carried out to summarize the main TCM syndrome types based on clinical practice.Results:The TCM syndrome type evolvement rule during radiotherapy and chemotherapy of nasopharyngeal carcinoma was preliminatively concluded,which could be classified int0 5 syndromes according to the results of cluster analysis.Conclusion:The TCM syndrome types can be divided into five categories:phlegm-stasis interformation syndrome,heat and toxicity with Yin(阴)injury syndrome,spleen deficiency and dampness obstruction syndrome,both Qi(气)and Yin deficiency syndrome,and Qi and blood deficiency syndrome.During the first week of radiotherapy,common symptoms included dry mouth and thirst,a lump in the neck,a pale or reddish-purple tongue,and a white,greasy tongue coating.During the third week of radiotherapy,common symptoms included dry and burning throat,sore throat,hypohydrin,sore ulcer,congestion of pharyngeal mucosa,yellowish or little tongue coating,and thin pulse.At the end of radiotherapy,symptoms included dryness and burning pharynx,sore pharynx,hypoglycemia,sore ulcer,congestion of the pharyngeal mucosa,fatigue,loss of appetite and listlessness,a pale or dark tongue,and a thin pulse or thin and fast pulse,etc.The evolution law of TCM syndrome type was that phlegm and blood stasis intermingled with each other in early stage.In the middle stage of chemoradiotherapy,Qi and Yin deficiency syndrome and heat-toxic Yin injury syndrome were increased.At the end of treatment,both Qi and Yin deficiency syndrome,Qi and blood deficiency syndrome were increased,phlegm-stasis intetjunction syndrome and heat-toxic Yin injury syndrome were decreased correspondingly.Spleen deficiency and dampness-blocking syndrome did not change significantly during radiotherapy and chemotherapy.The difference between groups was statistically significant(P＜0.05).However,its scientificity and practicability need further clinical verification.
Nasopharyngeal carcinomaChemoradiotherapySyndrome differentiation and classificationCluster analysis
万方数据
维普
