Experience of HOU Yangshao in treating EGFR-TKIs-induced rash in lung cancer patients
This paper summarizes the experience of the Chief Physician HOU Yangshao in treating skin rash reduced by epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs)in patients with lung cancer.Lung cancer is one of the most common malignant tumors in the world.The incidence and mortality of lung cancer patients in China are increasing year by year.With the continuous updating of lung can-cer treatment drugs,EGFR-TKIs has become a routine treatment for lung cancer patients with epidermal growth factor receptor(EGFR)gene mutation,and it is widely used in clinical practice.Compared with traditional chemotherapy drugs,EGFR-TKIs has the advantages of longer survival and fewer adverse reactions.However,the adverse reactions such as rash and pruritus accompanying EGFR-TKIs treatment still affect patients'quality of life and medication compliance.Traditional Chinese medicine has unique advantages in the treatment of lung cancer,which can alleviate the adverse reactions of radiotherapy and chemotherapy,targeted treatment and immunotherapy,relieve the symptoms of patients and prolong the survival cycle.Chief Physician HOU Yangshao believes that lung cancer patients suffer from heat toxin accumulation in the lung and body deficiency,after the treatment of EGFR-TKIs,the lung and spleen are injured by the toxic pathogens,and the dampness and heat are endogenous,which can cause skin rash through the surface.The main syndrome type of lung cancer patients after EGFR-TKIs treatment can be attributed to damp-heat syndrome combined with lung Qi(气)defi-ciency.Therefore,Chief Physician HOU Yangshao advocates the treatment principle of clearing heat and detoxification,drying dampness and relieving itching,invigorating spleen and tonifying lung,and designs Fuzheng Jiedu Yiliu formula(扶正解毒抑瘤方),which is applied in clinical practice.In addition,in the treatment of lung cancer,the mentor attaches importance to the treatment concept of"treating the same disease with the same symptoms by the same treatment method".In clinical practice,according to the symptoms of patients,the mentor adds and subtracts on the basis of the self-designed Fuzheng Jiedu Yiliu Formula and achieves good therapeutic effects.The article briefly eluminates the experience of the mentor,Chief Physician HOU Yangshao,in treating skin rash reduced by EGFR-TKIs in patients with lung cancer.One case is attached to prove it.
Lung cancerEpidermal growth factor receptor-tyrosine kinase inhibitorRashFuzheng Jiedu Yiliu formulaTreating the same disease with the same symptoms by the same treatment method
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