Network pharmacology-based research on the mechanism of action of Baishao in the treatment of chronic atrophic gastritis
Objective:The network pharmacology method was used to examine the mechanism of action of Baishao(Radix Paeoniae Alba)in the treatment of chronic atrophic gastritis(CAG).Methods:The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)was used to obtain information on the active ingredients and corresponding targets of Baishao.The information on targets associated to CAG was acquired through GeneCards,OMIM and DisGeNET databases,and drug-disease target intersection was retrieved through Venny 2.1.0.Active ingredient-target network diagram and PPI network diagram were generated using Cytoscape 3.7.1 and STRING databases,and then visualized.The DAVID database was used to conduct the Gene Ontology(GO),Kyoto Encyclopedia of Gene and Genomes(KEGG)enrichment study.Finally,Cytoscape 3.7.1 software was used to map the drug component-target-pathway-disease network diagram.Results:A total of 8 active components,72 targets,972 disease targets,and 34 intersections were discovered.Kaempferol,beta-sitosterol,(+)-catechin,AKT1,TNF,IL-6 were important active components and genes.Baishao primarily participated in the positive regulation of apoptotic process,response to drug,inflammatory response,and other biological processes to treat CAG by regulating signal pathways such as pathways in cancer,AGE-RAGE signaling pathway in diabetic complications,Epstein-Barr virus infection.Molecular docking results showed that the selected drug active ingredients have good binding activity with key targets.Conclusion:This research has preliminarily identified the anti-CAG mechanism of Baishao,laying the groundwork for both the creation of novel medications and the TCM treatment of CAG.
万方数据
维普
