基于数据挖掘探讨肿块期肉芽肿性小叶性乳腺炎的用药规律
An analysis of medication regularity of granulomatous lobular mastitis in mass stage based on data mining
李梅 1马宏博 2李昕 1李梦1
作者信息
- 1. 山东中医药大学,山东 济南,250014
- 2. 山东第一医科大学附属省立医院,山东 济南,250021
- 折叠
摘要
目的:基于数据挖掘的方法探讨文献中中药治疗肿块期肉芽肿性小叶性乳腺炎(Granulomatous Lobular Mastitis,GLM)的用药规律和组方配伍特点.方法:利用计算机检索 1980 年(维普为收录起始年)至 2022 年中国知网、万方数据库、维普期刊资源整合服务平台、中国生物医学文献数据库中关于中药治疗肿块期GLM的文献,严格筛选符合纳入标准的文献,利用Excel建立肿块期GLM规范化方药数据库,采用数据挖掘的方法对中药的功效类别、性味归经等进行频数统计分析以及关联规则和系统聚类分析.结果:纳入中药复方 47 首,涉及中药 111 味,累计药物使用频次 574 次,用药频次较高的药物包括柴胡、皂角刺、白芥子、蒲公英、熟地黄等,常用的中药功效类别为理气药、化痰药,四气多为寒、温,五味多为苦、辛,归经前 3位分别为肝经、脾经、胃经.经关联规则分析,得出潜在配伍组合共 16 组,为白芥子、麻黄、熟地黄、炮姜、肉桂、香附的加减组合.聚类分析挖掘出5个核心组方.结论:中药治疗肿块期GLM多采用温阳散结、理气化痰之法.
Abstract
Objective:To explore the medication regularity and compatibility of TCM medicine in the treatment of granulomatous lobular mastitis in the literature based on the method of data mining.Methods:The papers about the treatment of granulomatous lobular mastitis with TCM medicine from 1980 to 2022 in CNKI,Wanfang data,VIP periodical resource integration service platform and Chinese biomedical literature database were searched by computer,and the studies that met the inclusion criteria were strictly screened.The standardized prescription database of granulomatous lobular mastitis in mass stage was established by Excel.The efficacy category and meridian tropism of TCM medicine were analyzed by the method of data mining,association rule analysis and systematic cluster analysis.Results:A total of 47 compound prescriptions of TCM medicine were included,involving 111 kinds of TCM medicine,and the cumulative use frequency of medicine was 574.The medicine with higher frequency included Chaihu(Radix Bupleuri),Zaojiaoci(Spina Gleditsiae),Baijiezi(Semen Brassicae),Pugongying(Herba Taraxaci),Shudihuang(Radix Rehmanniae Preparata)and so on.The commonly used efficacy categories of TCM medicine were regulating Qi(气)and resolving phlegm,most of the four Qi were cold and warm,and most of the five flavors were bitter and pungent,and the top three meridians were liver,spleen and stomach meridians.Through the analysis of association rules,it was concluded that there were 16 groups of potential compatibility combinations,which were the addition and subtraction combinations of Baijiezi,Mahuang(Herba Ephedrae),Shudihuang,Paojiang(Rhizoma Zingiberis Preparatum),Rougui(Cortex Cinnamomi)and Xiangfu(Rhizoma Cyperi).Five core groups were excavated by cluster analysis.Conclusion:The method of warming Yang(阳),regulating Qi and resolving phlegm is often used in the TCM treatment of granulomatous lobular mastitis.
关键词
肉芽肿性小叶性乳腺炎/肿块期/中药/数据挖掘/用药规律Key words
Granulomatous lobular mastitis/Mass period/TCM medicine/Data mining/Medication rule引用本文复制引用
基金项目
国家中医药局"李克勤全国名老中医药专家传承工作室"建设项目(国中医药办人教函[2018]134)
国家中医药局全国中医(临床、基础)优秀人才研修项目(第四批)(国中医药人教发[2017]24号)
山东省中医药科技计划面上项目(2020M042)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据