An analysis of the interaction between intestinal flora disorder and chronic kidney disease based on the theory of enteric-renal axis
Intestinal flora is involved in many important links such as disease progression,diagnosis,metabolism and rehabilitation,and it has been confirmed that the disturbance of the flora is directly related to the increase of the incidence of chronic kidney disease.On the other hand,during chronic kidney disease,changes in microbial diversity accompanied by varying degrees of homeostasis imbalance can further aggravate renal damage and induce pathological malignant changes.In addition,immune disorders,metabolic disorders and inflammatory stress caused by chronic kidney disease have also been confirmed to be closely related to intestinal flora disorders,and this feature has a bidirectional structural relationship.The proposal of the gut-kidney axis concept clarified the possibility of intestinal microbial imbalance,intestinal barrier damage and toxin product accumulation damaging renal function,providing a microbiological basis for the interpretation and research of acute and chronic kidney injury,intestinal flora imbalance and related pathological mechanisms,and constantly derived the medical intervention target of treating kidney disease from intestine.The interaction between chronic kidney disease and intestinal flora will help to ameliorate the microecological imbalance and renal function damage.Therefore,this paper focuses on sorting out the complex interaction and metabolic pathway between intestinal flora and chronic kidney disease,and summarizes the endogenous mechanism of interaction between intestinal flora and chronic kidney disease,with a view to revealing the important role of microbial microecological imbalance in the occurrence and development of chronic kidney disease through the entero-renal axis,as well as the strategies and ways to maintain dynamic balance between the two,so as to further enrich the scientific connotation and material basis of the gut-kidney axis theory,and constantly provide new ideas and new methods for the prevention and control of intestinal flora disorders and chronic kidney disease.
Enteric-renal axisChronic kidney diseaseIntestinal floraInteractionMetabolism of matter
万方数据
维普
