目的:探讨补益肝肾中药治疗膝骨关节炎的临床疗效及安全性.方法:计算机检索中国知识资源总库、中国生物医学文献数据库、维普全文数据库等数据库中关于补益肝肾中药治疗膝骨关节炎的临床随机对照研究,依据Cochrane系统评价方法评估文献质量,运用Review Manager 5.4.1软件进行Meta分析.结果:最终纳入随机对照试验19篇,涉及患者1969例,其中治疗组(补益肝肾中药)1053例、对照组(常规治疗)916例.Meta分析结果显示:与对照组相比,治疗组总有效率较高[RR= 1.18,95%CI(1.13,1.23),P＜0.00001],不良反应发生率较低[RR = 0.32,95%CI(0.19,0.55),P＜0.0001],且在改善患者视觉模拟评分法(Visual Analogue Scale,VAS)评分、美国西安大略和麦克马斯特大学骨关节炎指数(the Western Ontario and McMaster Universities Osteoarthritis Index,WOMAC)评分、Lequesne指数、Lysholms评分、压痛值及中医证候评分等方面具有一定优势,差异均存在统计学意义.结论:运用补益肝肾中药治疗膝骨关节炎能有效改善患者临床症状,提高生活质量且安全性较高.由于纳入文献在样本量及质量上仍然存在一定欠缺,以上结论还期待更多高质量、大样本、双盲临床随机对照试验来进一步验证.
A Meta-analysis of clinical efficacy and safety of TCM medicine for tonifying the liver and kidney on knee osteoarthritis
Objective:To investigate the clinical efficacy and safety of TCM medicine for nourishing liver and kidney on knee osteoarthritis.Methods:Clinical randomized controlled trials of treating knee osteoarthritis with Chinese medicinal materials for nourishing liver and kidney were retrieved from databases such as CNKI,China biomedical literature database,and VIP.The quality of the literature was assessed according to the Cochrane systematic review method,and the software Review Manager 5.4.1 was used for data Meta-analysis.Results:In the end,a total of 19 RCTs were included,with a total of 1969 patients,including 1053 patients in the experimental group(TCM medicine for nourishing the liver and kidney),and 916 patients in the cortrol group(conventional treatment).The results of Meta-analysis showed that compared with the control group,the total effective rate in the experimental group was higher[RR=1.18,95%CI(1.13,1.23),P＜0.00001],and the incidence of adverse reactions in the experimental group was lower[RR=0.32,95%CI(0.19,0.55),P＜0.0001].It has certain advantages in improving patients'VAS score,WOMAC score,Lequesne index,Lysholms score,tenderness value and TCM syndrome score,and the differences were statistically significant.Conclusions:The treatment of knee osteoarthritis with TCM medicine for nourishing the liver and kidney can effectively ameliorate the clinical symptoms of patients,improve the quality of life,and has high safety.Due to the lack of sample size and methodological quality of the included literature,this conclusion needs more high-quality,large-sample,and double-blind clinical randomized controlled trials to continuously confirm.
Nourishing liver and kidneyKnee osteoarthritisClinical randomized controlled trialMeta-analysis
万方数据
维普
