A Meta-analysis of efficacy and safety of the integrated medicine on coronary heart disease with diabetes
Objective:To systematically evaluate the efficacy of the integrated medicine in the treatment of coronary heart disease complicated with diabetes,in order to provide a more reasonable clinical treatment plan.Methods:Chinese Journal full-text Database(CNKI),Wanfang(WANFANG)database and Chinese Sci-tech Journal full-text database(VIP)were searched by computer.From the establishment of the database to October 2022,randomized controlled trials(RCTs)of traditional Chinese medicine plus western medicine in the treatment of coronary heart disease complicated with diabetes mellitus were collected.Cochrane bias risk assessment tool was used to evaluate the bias risk of the included study.RevMan 5.3 software was used to evaluate the methodological quality of the included study.STATA 15.1 software was used for a statistical analysis.Results:A total of 18 RCT articles were included,including 1 478 patients.The results of Meta-analysis showed that the effective rate in the experimental group was significantly higher than that in the control group[OR = 2.78,95％CI(2.26,3.41),P<0.001],and the blood glucose in the experimental group was significantly lower than that in the control group[SMD =-0.45,95％CI(-0.56,-0.34),P<0.001].The level of low density lipoprotein cholesterol in the experimental group was decreased significantly[MD =-0.49,95％CI(-0.60,-0.38),P<0.01],and the ECG in the experimental group was significantly ameliorated[OR = 2.47,95％CI(1.63,3.74),Z = 4.268,P<0.05].There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion:Compared with western medicine alone,the integrated medicine on coronary heart disease complicated with diabetes can significantly improve the clinical efficacy,reduce the level of blood glucose and low density lipoprotein cholesterol,and has good safety.Huangqi(Radix Astragali)-Danshen(Radix et Rhizoma Salviae Miltiorrhizae)-Gegen(Radix Puerariae Lobatae)compatibility is a commonly used drug compatibility scheme in the TCM treatment of coronary heart disease complicated with diabetes,which provides a direction for future clinical application and basic research.
The integrated medicineCoronary heart diseaseDiabetesMeta-analysis
NETL
NSTL
万方数据
维普
