New advances in the treatment of coronary heart disease of the Qi deficiency and blood stasis syndrome with the Yiqi Huoxue prescription
Coronary heart disease is the main causes of human death worldwide,with high disability rate and mortality,the pathological mechanism include coronary lipid disorders,thrombosis,inflammation,vascular smooth cell activation or remodeling,platelet activation,endothelial dysfunction,oxidative stress,matrix metabolic changes and genetic factors.Although the pathological mechanism of coronary heart disease is relatively clear,secondary prevention drugs also effectively delay the disease progression,and reduce mortality,the number of coronary heart disease is still rising.Existing drug treatment target is single,and lack of drugs acting on a multitarget and multipathway site.In recent years,traditional Chinese medicine has achieved fruitful results in the cognition and action mechanism of treatment of coronary heart disease.Coronary heart disease belongs to the category of chest obstruction and heartache in traditional Chinese medicine.Qi(气)deficiency and blood stasis syndrome are the most common clinically,and supplementing Qi and promoting blood circulation is the main treatment rule.By consulting a large amount of relevant information,this paper sorted out the treatment of coronary heart disease of the Qi deficiency and blood stasis syndrome by supplementing Qi and promoting blood circulation in the past five years,the mechanism of action is abundant,mainly includes improving hemorheology,protecting vascular endothelium,inhibiting inflammatory response,fighting oxidative stress response,improving ventricular structure and cardiac function,regulating lipid to stabilize plaque,improving coronary blood flow/slow blood flow,ameliorating myocardial injury,etc..These large number of research results show that on the basis of secondary preventive drugs,the addition of supplementing Qi and promoting blood circulation prescription in the treatment of coronary heart disease of the Qi deficiency and blood stasis syndrome can expand the therapeutic targets and pathways of the disease.Compared with modern medicine,this therapy has a certain theoretical reference for the later clinical practice and research.
Supplementing Qi and promoting blood circulation methodQi deficiency and blood stasis syndromeCoronary heart diseaseCardiovascular
NETL
NSTL
万方数据
维普
