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董筠教授从中焦肝脾论治非酒精性脂肪性肝病

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非酒精性脂肪性肝病是一种与胰岛素抵抗和遗传易感密切相关的代谢应激性肝损伤,疾病谱包括非酒精性单纯性肝脂肪变、非酒精性脂肪性肝炎、肝硬化和肝细胞癌.非酒精性脂肪性肝病全球患病率高达 25%,已然成为中国第一大慢性肝病,与肥胖、2 型糖尿病、代谢综合征、动脉粥样硬化、心脑血管疾病等关系密切.现代医学尚无理想的治疗药物,本病初期西医主要通过低脂饮食和控制体质量进行管理.中医药治疗该病具有多靶点、多通路、多向调节的特点,不仅能改善患者的临床症状,而且在降血脂、保肝降酶、阻止肝纤维化进展等方面均有优势.董筠教授从中焦肝脾论治该病,认为其核心病机乃脾虚湿滞;病理关键是脾失健运、痰浊内阻;病理本质在于中焦肝脾同病,以脾虚为本、木乘为标.董师强调本病肝气乘脾的根源不在肝而在脾,在于脾失健运而气机升降失常,以致水谷不能化生精微反停而成水湿,聚而生痰浊,久则痰瘀互结.因此,治疗上董师强调从脾治肝,健脾升清以复肝常,化湿降浊以祛痰瘀,转枢中焦,诸脏皆安.文章介绍了董筠教授治疗非酒精性脂肪性肝病的临床经验,附医案一则加以佐证,以期为临床诊疗提供参考.
Professor DONG Jun's experience in treating non-alcoholic fatty liver disease from middle-Jiao liver and spleen
Nonalcoholic fatty liver disease(NAFLD)is a metabolic stress liver injury closely related to insulin resistance and genetic susceptibility.The disease spectrum includes nonalcoholic simple steatosis,nonalcoholic steatohepatitis,liver cirrhosis and hepatocellular carcinoma.The global prevalence of NAFLD is as high as 25%,and it has become the largest chronic liver disease in China.NAFLD is closely associated with obesity,type 2 diabetes,metabolic syndrome,arteriosclerosis,cardiovascular and cerebrovascular diseases.Modern medicine has no ideal treatment drugs,mainly through low-fat diet and weight control management.Traditional Chinese medicine has the characteristics of multi-targets,multi-pathways and multi-directions regulation.It can not only improve the clinical symptoms of patients,but also has advantages in lowering blood fat,protecting liver and lowering enzyme,and preventing the progress of liver fibrosis.Professor DONG Jun treated the disease from the point of liver and spleen in middle-Jiao(中焦).The professor thought that the core pathogenesis of the disease was spleen deficiency and dampness stagnation,the key point of pathology was that the spleen lost the function of transport,and phlegm and turbid internal obstruction,the essence of pathology was that the liver and spleen in middle-Jiao had the same disease,taking spleen deficiency as the root cause and liver subjugating spleen as the superficial symptom.DONG stressed that the root cause of liver Qi(气)subujgating spleen in this disease lies not in the liver but in the spleen.It lies in the loss of healthy movement of the spleen and the abnormal rise and fall of Qi,so that the body can not absorb nutrition,resulting in dampness and phlegm turbidity,and then phlegm and blood stasis intertwine.Therefore,in the treatment,Professor DONG emphasized treating the liver from the spleen,strengthening spleen sending up essential substances to recover the function of liver,resolving dampness and lowering turbidity to remove phlegm and blood stasis,turning on the central focus,and then all the viscera are safe.The author summarized Professor DONG Jun's clinical experience in the treatment of non-alcoholic fatty liver disease as follows,with one medical case to support,in order to provide reference for clinical diagnosis and treatment.

Non-alcoholic fatty liver diseaseMiddle-JiaoLiverSpleenTreating liver from spleen

孙倩倩、董筠

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南京中医药大学附属医院,江苏 南京,210029

非酒精性脂肪性肝病 中焦 从脾治肝

江苏省中医院科主任提升专项(2021)

Y2021ZR18

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(8)
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