Exploring the prescription regularity rule of TCM in treating spontaneous pneumothorax based on data mining technology
Objective:To analyze the prescription regularity rule of TCM on spontaneous pneumothorax,so as to provide useful reference for clinical treatment.Methods:Literature about prescriptions for spontaneous pneumothorax from the database of CNKI,VIP,Wanfang,and CBM was searched from inception to February 28,2023.The TCMISS V2.5 was used to analyze the use frequency of herb,herb-pairs and herb combinations commonly used.The association rule,revised mutual information,and complex system entropy clustering were used to analyze the herb association rules and core herb combinations.The unsupervised entropy hierarchical clustering was used for new prescription analysis.Results:A total of 187 prescriptions were screened,involving 237 kinds of herb.There were 55 kinds of herb with frequency more than 10,such as Gancao(Radix Glycyrrhizae),Huangqi(Radix Astragali),Fuling(Poria),Wuweizi(Fructus Schisandrae Chinensis),Baizhu(Rhizoma Atractylodis Macrocephalae),etc.,which were mainly composed of herbs for tonify,resolving phlegm and relieving cough and asthma,invigorating blood circulation and eliminating stasis,regulating Qi(气),heat-clearing,and water-disinhibiting damp-percolating.A total of 24 high-frequency herb combinations were obtained by association rule analysis,such as Baizhu-Fuling,Gancao-Fuling,Huangqi-Danggui(Radix Angelicae Sinensis),Dangshen(Radix Codonopsis)-Huangqi,Maidong(Radix Ophiopogonis)-Gancao,etc..The core of the association network was composed of Gancao,Huangqi,Fuling,Baizhu,Wuweizi,Danggui,etc..A total of 30 core herb combinations and 15 potential new prescriptions were obtained by entropy hierarchical clustering.Conclusion:Spontaneous pneumothorax treated in TCM revolved around the characteristics of deficiency,phlegm,stasis and depression.The core treatment methods were nourishing Qi and protecting lungs,resolving phlegm and relieving cough,invigorating blood circulation and eliminating stasis,and activating Qi to excrete water,which reflected the treatment ideas of treating disease from the aspects of lung,liver,spleen and kidney together,and considering both deficient root and excessive symptoms.
NETL
NSTL
万方数据
维普
