Taking the combination of Fuzi and Banxia as an example to explore the historical origins and clinical application prospects of eighteen incompatible medicaments
Eighteen incompatible medicaments has a long history,which has been regarded as a rule and rarely overstepped by doctors of all dynasties,especially when eighteen incompatible medicaments was record in Rumen Shiqin(《儒门事亲》),which made it a basic method for students to learn TCM.Since then,it has been widely spread that even the ancient scholars who did not engage in traditional Chinese medicine were mostly aware of the eighteen incompatible medicaments and used them to test the knowledge of TCM.In this particular period,even though some doctors have doubts about eighteen incompatible medicaments,they do not dare to try it easily.This has led to the eighteen incompatible medicaments becoming a taboo for compatibility.However,the underlying mechanism of the eighteen incompatible medicaments has not been explored,nor has anyone dared to challenge or exceed it,as far as the modern world is concerned.Since modern times,the eighteen incompatible medicaments have been included in the pharmacopoeia of the people's republic of China,which seems to further prove the rationality of eighteen incompatible medicaments.However,the toxicity and mechanism of eighteen incompatible medicaments still need to study.With the progress of modern science and technology,the rapid development of pharmacological research,it may be due to the complexity of eighteen incompatible medicaments,many pharmacology have little research on the medicaments,which has led to the argument and has not yet formed a unified understanding.In this paper,the historical origin of eighteen incompatible medicaments is systematically expounded,the precedents of the application of eighteen incompatible medicaments in the works of medical experts are enumerated.Taking Fuzi(Radix Aconiti Lateralis Preparata)and Banxia(Rhizoma Pinelliae)as an example,the modern pharmacological research and modern medical application system are summarized,showing that although eighteen incompatible medicaments have certain scientific truths,they are not completely in line with pharmacology.And after reasonable compatibility and processing,when necessary,they can not only be applied clinically,without obvious adverse reactions.For critical and difficult diseases,although the pharmacological effects of medicines are opposite,it can have a better therapeutic effect.
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