A review on the mechanism of TCM medicine on oxidative stress in diabetic retinopathy
Diabetic retinopathy(DR)refers to retinal microvascular disease in diabetic patients,characterized by intraretinal hemorrhage,hard exudation,cotton wool spots,macular edema,microangioma,etc.,and in severe cases,traction retinal detachment and visual impairment may occur.As one of the most common microvascular complications of diabetes,DR has a high incidence of blindness,and its morbidity ranks first in the working population.Diabetes belongs to the category of diabetes in TCM,DR is also known as sparrow eyes,dimmed vision,blood flooding pupils,cloudy eyes or sudden blindness.Modern TCM calls DR dispersion-thirst eye disease.Since ancient times,many predecessors have studied the pathological mechanism and treatment of dispersiom-thirst eye disease,which has laid a foundation for the understanding and treatment of DR in modem TCM.At present,the pathogenesis of DR is not completely clear.Studies have shown that oxidative stress is one of the important cellular mechanisms in diabetic complications,which can induce apoptosis,microvascular damage,and lead to the damage of blood-retinal barrier,eventually leading to the occurrence of DR.How to effectively prevent and treat DR is an urgent problem to be solved.Treatment methods such as laser photocoagulation and anti-vascular endothelial growth factor drugs are effective,but their limitations and adverse reactions cannot be ignored.In recent years,the research on the prevention and treatment of DR in TCM has been increasing.TCM has played its unique advantages in the treatment of DR,and it can complement Western medicine treatment.This article reviews the relationship between the mechanism of oxidative stress and DR,and the related TCM medicine monomers that intervene in the oxidative stress pathway of DR,in order to provide some thinking for the systematic prevention and treatment of DR in the integrated medicine.
Diabetic retinopathyOxidative stressMonomers of TCM medicineResearch progress
万方数据
维普
