A study on the mechanism of the Linggui Zhugan decoction in the treatment of chronic heart failure based on network pharmacology
Objective:To screen the active ingredients and core targets of the Linggui Zhugan decoction(苓桂术甘汤)based on network pharmacology,and further explore the potential molecular mechanism in the prevention and treatment of chronic heart failure(CHF).Methods:The bioactive components of the Linggui Zhugan decoction were retrieved from the TCM system pharmacological analysis platform(TCMSP),and the target of active components was predicted.Disease targets of CHF were screened using GeneCards database.The common targets of drugs and diseases were screened using R language software,and the interaction network of active drug ingredients and disease targets was constructed using Cytoscape 3.7.2 software.The common target protein interaction network was constructed using STRING 11.0,and topological analysis was carried out on PPI using Cytoscape 3.7.2.The common targets gene ontologyenrichment analysis and Kyoto encyclopedia of genes and genomes pathway enrichment analysis were carried out using R language software.Meanwhile,Cytoscape 3.7.2 software was used to construct the interaction network of KEGG pathway and enriched protein.Results:A total of 95 effective bioactive components of the Linggui Zhugan decoction were obtained,with 72 targets related to CHF.These targets were mainly involved in biological processes such as the response to nutrient level,the reaction of lipolysaccharide,the vascular process in the circulatory system and the reaction of reactive oxygen species.It was mainly enriched in the signaling pathways of AGE-RAGE in the complications of diabetes,fluid shear stress and atherosclerosis,tumor necrosis factor,and the core target proteins were mainly mitogen-activated protein 1,mitogen-activated protein 14,AKT1,matrix metalloproteinase 9,vascular endothelial growth factor A and so on.Conclusion:The Linggui Zhugan decoction has the characteristics of multi-component,multi-target and multi-pathway in the prevention and treatment of CHF,and the potential mechanism of action of the Linggui Zhugan decoction in the treatment of CHF was speculated,which provides a certain theoretical basis for further research on the pharmacodynamic material basis in the treatment of CHF.
Network pharmacologyThe Linggui Zhugan decoctionChronic heart failureMechanism of action
万方数据
维普
