A study on the distribution rule of syndrome elements of Helicobacter pylori infection-related diseases
Objective:To explore the distribution rule of TCM syndromes and syndrome elements of Helicobacter pylori(Hp)infection-related diseases.Methods:Relevant studies were retrieved from CNKI,VIP and Wanfang databases,and information on syndromes and syndrome elements was extracted to establish the database.Microsoft Office Excel 2019 was used for descriptive statistics.IBM SPSS Modeler 18.0 was used for an association rule analysis to explore the distribution rule of TCM syndrome elements.Results:① A total of 312 studies were included,including 28 syndrome types,among which the dampness-heat in spleen and stomach type,the disharmony between liver and stomach type and Yin(阴)deficiency of stomach type appeared most frequently.A total of 6 disease location syndrome elements and 14 disease property syndrome elements were extracted.The disease location syndrome elements mainly distributed in the stomach,spleen and liver,and the high-frequency disease property syndrome elements were heat,dampness,Yin deficiency,Qi(气)deficiency,Yang(阳)deficiency and blood stasis,which indicated the disease was stubborn,and the syndrome of deficiency-excess mixing was common.② Among the various combinations,the most frequent combination of two syndrome elements was"liver+stomach",the most frequent combination of three syndrome elements was"Yang deficiency+spleen+stomach",and the most frequent combination of four syndrome elements was"dampness+heat+spleen+stomach".The combination form reveals to a certain extent the close relationship between the liver and the Hp infection-related disease,suggesting the disease tendencies of chronic illness injuring Yang,and the adhesion and retention of dampness and heat in the body.③The analysis of association rules showed that dampness,heat,spleen,and stomach had the strongest correlation with each other,which was exactly in line with the characteristics of the dampness,heat,and toxicity pathogenic factors of Hp,suggesting that dampness-heat obstruction in the spleen and stomach was the core pathogenesis of this disease.Conclusion:The pathogenesis of Hp infection-related diseases is based on heat in stomach and dampness in spleen.Failure of liver to convey and disperse nutrient substance is the key point,and deficiency-excess mixing is the main outcome in the later stage.Syndrome differentiation should pay attention to distinguish the severity of dampness and heat,and the primary and secondary relationship between deficiency and excess,and then use the methods of clearing heat and resolving dampness,smoothing liver and regulating Qi,and activating blood circulation and removing stasis to treat the disease.
Helicobacter pyloriTraditional Chinese medicineSyndrome elementData mining
万方数据
维普
