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阻塞性睡眠呼吸暂停综合征中医证型分布的Meta分析

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目的:运用系统评价方法,定量分析我国阻塞性睡眠呼吸暂停综合征(Obstructive Sleep Apnea Hypopnea Syndrome,OSAHS)中医证型分布频率,为临床诊疗提供循证医学依据.方法:计算机检索中国知网、万方数据库、维普中文期刊服务平台、中国生物医学文献数据库(CBM)、PubMed、Embase、Web of science及Cochrane数据库,检索时间为建库至2023 年 10 月 31 日.由 2 名研究者根据纳入和排除标准独立筛选文献,提取数据并交叉核对,运用美国卫生保健质量和研究机构横断面研究量表进行文献质量评价,使用Stata SE-64软件进行Meta分析.结果:最终共纳入18篇文献.Meta分析结果显示:痰湿阻滞证分布频率为 0.288[95%置信区间(CI)(0.238,0.341)];痰瘀互结证分布频率为 0.250[95%CI(0.190,0.316)];痰热蕴结证分布频率为 0.225[95%CI(0.161,0.296)];肺脾气虚证分布频率为 0.155[95%CI(0.126,0.187)];气阴两虚证分布频率为0.129[95%CI(0.065,0.210)];气滞血瘀证分布频率为0.117[95%CI(0.069,0.175)];脾肾两虚证分布频率为0.117[95%CI(0.086,0.152)];肝郁气滞证分布频率为 0.111[95%CI(0.007,0.307)].亚组分析显示痰热蕴结证、痰瘀互结证在性别方面的差异有统计学意义(P<0.05),痰湿阻滞证、痰瘀互结证、肺脾气虚证在患病严重程度上差异有统计学意义(P<0.05).结论:OSAHS以痰湿阻滞证、痰瘀互结证、痰热蕴结证分布较多,不同性别、不同患病严重程度对OSAHS个别中医证候有一定影响.
A Meta-analysis of the distribution of TCM syndrome in OSAHS
Objective:Using the method of Meta-analysis,the distribution frequency of TCM syndromes of obstructive sleep apnea-hypopnea syndrome(OSAHS)was analyzed quantitatively to provide an evidence-based medical basis for clinical diagnosis and treatment.Methods:CNKI,Wangfang,VIP,CBM,PubMed,Embase,Web of science and Cochrane library were searched by computer from the foundation of databases to 31 October,2023.Two researchers screened the literature according to the inclusion and exclusion criteria,extracted and cross-checked the information,the Agency for Healthcare Research and Quality(AHRQ)cross-sectional research scale was used for quality evaluation.And then a Meta-analysis was performed by Stata SE-64 software.Results:Eighteen studies were included in this study.The results of Meta-analysis showed that the distribution frequency of phlegm-dampness block syndrome was 0.288[95%CI(0.238,0.341)].The distribution frequency of phlegm and blood stasis intermingle syndrome was 0.250[95%CI(0.190,0.316)].The distribution frequency of phlegm heat accumulation syndrome was 0.225[95%CI(0.161,0.296)].The distribution frequency of lung-spleen Qi(气)deficiency syndrome was 0.155[95%CI(0.126,0.187)].The distribution frequency of Qi and Yin(阴)deficiency syndrome was 0.129[95%CI(0.065,0.210)].The distribution frequency of Qi stagnation and blood stasis syndrome was 0.117[95%CI(0.069,0.175)].The distribution frequency of spleen-kidney deficiency syndrome was 0.117[95%CI(0.086,0.152)].The distribution frequency of liver depression and Qi stagnation syndrome was 0.111[95%CI(0.007,0.307)].Subgroup analysis showed that there was a statistically significant difference between the distribution of phlegm heat accumulation syndrome and phlegm and blood stasis intermingle syndrome in genders(P<0.05).There was a statistically significant difference among the distribution of phlegm-dampness block syndrome,phlegm and blood stasis intermingle syndrome,and lung-spleen Qi deficiency syndrome in different degrees of disease(P<0.05).Conclusion:Phlegm-dampness block syndrome,phlegm and blood stasis intermingle syndrome and phlegm heat accumulation syndrome are more common in OSAHS.Different genders and different degrees of disease have an impact on individual TCM syndromes of OSAHS.

Obstructive sleep apnea hypopnea syndromeTCM syndrome typeMeta-analysis

马一文、孙琳园、张弘

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浙江中医药大学,浙江 杭州,310000

浙江中医药大学附属第一医院(浙江省中医院),浙江 杭州,310000

阻塞性睡眠呼吸暂停综合征 中医证型 Meta分析

浙江省中医药科技计划

2021ZZ018

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(13)
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