A Meta-analysis of the distribution of TCM syndrome in OSAHS
Objective:Using the method of Meta-analysis,the distribution frequency of TCM syndromes of obstructive sleep apnea-hypopnea syndrome(OSAHS)was analyzed quantitatively to provide an evidence-based medical basis for clinical diagnosis and treatment.Methods:CNKI,Wangfang,VIP,CBM,PubMed,Embase,Web of science and Cochrane library were searched by computer from the foundation of databases to 31 October,2023.Two researchers screened the literature according to the inclusion and exclusion criteria,extracted and cross-checked the information,the Agency for Healthcare Research and Quality(AHRQ)cross-sectional research scale was used for quality evaluation.And then a Meta-analysis was performed by Stata SE-64 software.Results:Eighteen studies were included in this study.The results of Meta-analysis showed that the distribution frequency of phlegm-dampness block syndrome was 0.288[95%CI(0.238,0.341)].The distribution frequency of phlegm and blood stasis intermingle syndrome was 0.250[95%CI(0.190,0.316)].The distribution frequency of phlegm heat accumulation syndrome was 0.225[95%CI(0.161,0.296)].The distribution frequency of lung-spleen Qi(气)deficiency syndrome was 0.155[95%CI(0.126,0.187)].The distribution frequency of Qi and Yin(阴)deficiency syndrome was 0.129[95%CI(0.065,0.210)].The distribution frequency of Qi stagnation and blood stasis syndrome was 0.117[95%CI(0.069,0.175)].The distribution frequency of spleen-kidney deficiency syndrome was 0.117[95%CI(0.086,0.152)].The distribution frequency of liver depression and Qi stagnation syndrome was 0.111[95%CI(0.007,0.307)].Subgroup analysis showed that there was a statistically significant difference between the distribution of phlegm heat accumulation syndrome and phlegm and blood stasis intermingle syndrome in genders(P<0.05).There was a statistically significant difference among the distribution of phlegm-dampness block syndrome,phlegm and blood stasis intermingle syndrome,and lung-spleen Qi deficiency syndrome in different degrees of disease(P<0.05).Conclusion:Phlegm-dampness block syndrome,phlegm and blood stasis intermingle syndrome and phlegm heat accumulation syndrome are more common in OSAHS.Different genders and different degrees of disease have an impact on individual TCM syndromes of OSAHS.