A eview on purslane polysaccharide in the treatment of ulcerative colitis
Ulcerative colitis(UC)is a kind of colorectal inflammatory bowel disease with high prevalence,which poses a serious threat to human life and health.However,the clinical treatment of UC in Western medicine has certain limitations.In recent years,with the in-depth development of the field of traditional Chinese medicine,researchers have found that TCM compounds and TCM monomers have unique advantages in interfering with the occurrence and development of UC at multiple levels,multiple pathways and multiple targets.Therefore,TCM compounds and TCM monomers have gradually become the focus of UC prevention and control research,and have attracted wide attention.It is found that portulaca polysaccharide has multiple mechanisms of action in the intervention of UC.First,it can regulate the biological barrier and reduce the invasion of harmful substances to the colon by enhancing the integrity of the mucosal barrier.Secondly,portulane polysaccharide improves the function of chemical barrier,promotes the secretion and differentiation of intestinal mucus,and increases the content of glycoprotein on the intestinal surface,thus enhancing the protective effect of mucosal barrier.Thirdly,portulaca polysaccharide can protect the mechanical barrier and reduce the degree of colon tissue damage by reducing inflammatory response and oxidative stress.Finally,portulaca polysaccharide also has a regulatory effect on the immune barrier,which can inhibit the activation of inflammatory cells and the release of inflammatory mediators,and reduce the overactivation of immune response.This paper systematically summarizes the mechanism of purslane polysaccharide on UC,including regulation of biological barrier,improvement of chemical barrier,protection of mechanical barrier and immune barrier.Through in-depth study of the research progress of purslane polysaccharide,it will provide new ideas and guidance for the treatment of UC and the research and development of traditional Chinese medicine Machixian(Herba Portulacae),Although the current study results show the potential of purslane polysaccharide in the treatment of UC,further clinical studies are needed to verify its safety and efficacy.It is hoped that more studies will focus on the application of TCM compounds and TCM monomers in the prevention and treatment of UC in the future,so as to provide more effective treatment strategies to improve the quality of life of UC patients.
万方数据
维普
