A Meta-analysis of the efficacy and safety of acupoint application in the adjuvant treatment of mycoplasma pneumoniae pneumonia in children
Objective:To systematically evaluate the therapeutic effect of acupoint application of Chinese medicine in the adjuvant treatment of mycoplasma pneumoniae pneumonia in children.Methods:All relevant Chinese and English studie were searched in CNKI,VIP,Wanfang and PubMed databases from the establishment of the database to March 2023.Randomized controlled trials involving acupoint application for adjuvant treatment of pediatric mycoplasma pneumoniae pneumonia were included.The Cochrane network bias risk assessment tool was used to evaluate the quality of the included litera-tures.Meta-analysis was performed using RevMan 5.4 software.Results:A total of 15 randomized controlled trials were included,with a total of 1 689 patients,846 cases in the treatment group and 843 cases in the control group.The results of Meta-analysis showed that Chinese medicine acupoint application in the adjuvant treatment of pediatric mycoplasma pneumonias pneumonia could significantly improve the effective rate[OR=4.66,95％CI(3.01,7.23),P＜0.000 1],and improve the cure rate[OR=3.05,95％CI(2.18,4.28),P＜0.000 01].It had faster relief of fever[MD=-1.39,95％CI(-1.58,-1.19),P＜0.000 01],cough symptoms[MD=-1.89,95％CI(-2.20,-1.57),P＜0.000 01],faster disappearance of lung rales[MD=-1.82,95％CI(-2.19,-1.46),P＜0.000 01].In the treatment group,the range of chest X-ray inflammation lesions was significantly reduced[MD=-2.5,95％CI(-3.18,-1.83),P＜0.000 01],and the inflammatory factor hypersensitive C-reactive protein(CRP)[MD=-5.35,95％CI(-9.27,-1.43).P=0.007]and tumor necrosis factor-α(TNF-α)[MD=-3.75,95％CI(-5.19,-2.86),P＜0.000 01]were decreased,and adverse reactions were also decreased[OR=0.43,95％CI(0.24,0.77),P=0.004].The differences were statistically significant(P＜0.05).Conclusion:Based on the current evidence,Chinese medicine acupoint application is effective in the adjuvant treatment of pediatric mycoplasma pneumo-niae pneumonia,the effective rate and cure rate have been significantly improved,and related symptoms(fever,cough,pulmonary rales)can be relieved faster,and inflammation and adverse reactions can be reduced.
Mycoplasma pneumoniae pneumonia in childrenAcupoint applicationExternal treatment of Chinese medicineMeta-analysis
万方数据
维普
