A clinical study on the prevention and treatment of oxaliplatin peripheral neurotoxicity by moxibustion at Jing points and Ying points based on the thought of preventive treatment of disease
Objective:The important means of TCM external treatment to prevent and treat oxaliplatin peripheral neurotoxicity was explored to provide a theoretical basis for the clinical transformation of TCM appropriate techniques and evidence support for the idea of preventive treatment of disease in TCM.Methods:Forty patients with gastrointestinal malignant tumor who were admitted to the First Hospital of Qiqihar from January to October 2022 and met the inclusion criteria were selected and were randomly divided into the experimental group and the control group.The control group was routinely given platinum-containing dual drugs plus chemotherapy,while the experimental group was additionally treated by TCM appropriate techniques,moxibustion insulated by Danshen(Salvia miltiorrhiza)powder on Yongquan points(KI1)and Laogong points(PC8).The occurrence of peripheral neurotoxicity,serum nerve growth factor(NGF),motor nerve conduction velocity and sensory nerve conduction velocity in the two groups were observed before and after treatment.Results:After treatment,the incidence of peripheral neurotoxicity in the experimental group was significantly lower than that in the control group(P＜0.05),with goade 0 and goade 1 adverse reactions as the main ones,and no peripheral neurotoxicity of grade 3 or above occurred.After treatment,the decrease of serum NGF in the experimental group was not significant compared with that in the control group(P＜0.01).After treatment,the decline level of ulnar nerve,radial nerve movement nerve conduction velocity and sensory nerve conduction velocity in the experimental group was not obvious compared with the control group(P＜0.05).Conclusion:Moxibustion at Yongquan points and Laogong points can prevent the occurrence of oxaliplatin peripheral neurotoxicity in patients with gastrointestinal malignant tumor.The mechanism may be to increase serum NGF level by regulating the conduction velocities of motor and sensory nerves,thus alleviating peripheral nerve injury.
Preventive treatment of diseaseMoxibustionPeripheral neurotoxicitySerum nerve growth factorOxaliplatin
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