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基于数据挖掘的含蒲公英藏药方剂的配伍规律

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目的:探讨含蒲公英藏药方剂的用药规律及含该药材方剂的配伍规律.方法:以《藏药晶镜本草》为标准,从《藏药方剂大全》和《秘诀补遗》中收集含蒲公英的藏药方剂,运用Excel 2019对含蒲公英的方剂进行数据整理,并且运用SPSS Modeler 18.0对药物进行频次统计和关联规则分析.结果:共收集到含蒲公英的方剂65首,方剂中共出现药物218味,药物出现的总频次为949,涉及主治疾病25种,其中出现频次≥10的疾病有8种,主要为木布病(35次)、中毒热(25次)、热病(20次)、创伤病(18次)等;涉及药材218味,使用频次≥13的药物共20味,蒲公英主要与熊胆(22次)、船盔乌头(21次)、兔耳草(20次)、渣驯(20次)等搭配使用;药味以甘、苦、涩为主,三化味以苦化味与甘化味为主,并以凉、钝、重、稀等药性治疗热性疾病;关联规则分析发现,实例、支持度、置信度均高的药物组合有42个,其中蒲公英-熊胆为二项关联规则,蒲公英-诃子与渣驯为三项关联规则,蒲公英-肉豆蔻、白豆蔻与渣驯为四项关联规则.结论:数据分析结果提示了含蒲公英藏药材主治疾病及其用药规律,为藏医临床合理用药和治疗热性木布病、中毒热、瘟疫等热性疾病新药开发提供了重要依据.
An analysis of the compatibility rules of traditional Tibetan medicine incorporating Pugongying based on data mining
Objective:To investigate the medication pattern and compatibility rules of Tibetan medicine prescriptions incorporating Pugongying(Herba Taraxaci).Methods:Based on The Stainless Crystal Mirror,traditional Tibetan medicine prescriptions incorporating Pugongying were collected from The Encyclopedia of Tibetan Medical Prescriptions and The Recipe Addendum,and the data of Pugongying incorporating prescriptions was sorted out using Microsoft Excel 2019.The frequency statistics and association rule of the drug in the database were analyzed through SPSS Modeler 18.0.Results:A total of 65 prescriptions incorporating Pugongying were collected,and a total of 218 drugs appeared in the prescriptions,the total frequency of drugs was 949 times,involving 25 kinds of diseases,of which 8 diseases with frequency not less than 10 times were mainly Mubu(木布)disease(35 times),toxic fever(25 times),fever(20 times),trauma disease(18 times),etc..It involved 218 kinds of medicinal materials,and there were 20 drugs with the frequency of not less than 13 times.Pugongying was mainly used in combination with bear bile(22 times),naviculare Wutou(Radix Aconiti Kusnezoffii)(21 times),Tuer cao(Herba Violae)(20 times),and faeces ochotonae erythrotis(20 times).The tastes of medicine were mainly sweet,bitter and astringent,and the three transforming tastes were bitter and sweet,and the medicine of treating heat diseases were cool,dull,heavy and thin.Association rule analysis showed that there were 42 associated drug combinations with high case,support and confidence,among which Pugongying-bear bile was a binomial association rule,Pugongying-Hezi(Fructus Chebulae)and faeces ochotonae erythrotis were a three-item association rule,and Pugongying-Roudoukou(Semen Myristicae),Baidoukou(Fructus Amomi Rotundus)and faeces ochotonae erythrotis were a four-item association rule.Conclusion:This article analyzes the main diseases and medication patterns of Tibetan medicine prescriptions incorporating Pugongying,providing important evidence for the rational use of drugs in clinical Tibetan medicine and the development of new drugs for the treatment of heat-related diseases such as Mubu disease,toxic fever,and plague.

Tibetan medicinePugongyingCompatibility ruleData mining

杰巴江村、晋美、嘎热

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西藏藏医药大学,西藏 拉萨,850000

比如县藏医院,西藏 那曲,850000

藏药 蒲公英 配伍规律 数据挖掘

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(16)