Research status and hot spot analysis of traditional Chinese medicine in the treatment of ulcerative colitis based on bibliometrics and visualization technology
Objective:To analyze the current status and hotspots of clinical research on traditional Chinese medicine for the treatment of ulcerative colitis.Methods:Clinical research literature on TCM treatment of ulcerative colitis was obtained by searching databases such as China Knowledge(CNKI),Wanfang database(WF),VIP database(VIP),and China Biomedical Medicine Literature Database(CBM).The latest publication date of the literature was March 31,2023.Screening of literature and creation of relevant databases was performed by NoteExpress 3.0 software.At the same time,based on bibliometric and statistical methods,the basic information of the collected and screened literature(including the time of publication,authors,producing organizations and keywords,etc.)was extracted.A hotspot analysis of TCM treatment of ulcerative colitis was carried out using Citespace 6.2 software.Results:① Based on the inclusion and exclusion criteria,a total of 2 160 articles were obtained from the literature.Between 1989 and March 2023,there is an overall upward trend in the number of articles issued.The rise in the number of publications after 2014 was greater than before,and the papers were mostly published in more specialized journals.Research on the treatment of UC with Chinese medicine has shown a trend of both quality and quantity.② The clinical research team of UC,represented by ZHU Yeshan,HE Fang,LIU Shiju,YANG Jie,has strong influence.Research institutions were relatively concentrated,mainly traditional Chinese medicine universities and their affiliates in Nanjing,Henan and Liaoning and other areas,but the degree of regional cooperation was low.③ Co-occurrence and cluster analysis of keywords in the included literature revealed that 13 keywords such as UC,clinical efficacy,mesalazine,herbal enemas,and inflammatory factors appeared frequently and with high centrality.④ Analysis of the keyword time line diagram and emergence diagram revealed that intestinal flora,oxidative stress,syndrome of damp and heat accumulation,and adverse reactions were the hotspots of research in recent years.⑤ After analyzing the literature,it is clear that although there are many interventions for ulcerative colitis,the combination of traditional Chinese medicine and Western medicine is still the most common treatment method at present.Conclusion:Although clinical studies on the treatment of UC in traditional Chinese medicine have made great progress,the mechanism of action is still unclear.Syndrome of damp and heat accumulation is the main syndrome of ulcerative colitis for the current study of ulcerative colitis;the combination of traditional Chinese medicine and Western medicine is the preferred therapeutic option for the treatment of UC;immunomodulation,oxidative stress and intestinal flora homeostasis are the main areas to be explored in the future;cross-regional linkages and operations are inevitable means of promoting UC research.
Ulcerative colitisTraditional Chinese medicineBibliometricsVisualizationHotspot
万方数据
维普
