基于数据挖掘探讨高天舒教授治疗甲状腺功能亢进症用药规律
Exploration on the medication rules of Professor GAO Tianshu in the treatment of hyperthyroidism based on data mining
彭泽栋 1陈思维 1臧春雪 2高天舒3
作者信息
- 1. 辽宁中医药大学,辽宁 沈阳,110000
- 2. 中国医科大学附属第四医院,辽宁 沈阳,110000
- 3. 辽宁中医药大学附属医院,辽宁 沈阳,110000
- 折叠
摘要
目的:基于中医传承辅助平台软件(V2.5)挖掘高天舒教授治疗甲状腺功能亢进症(简称甲亢)的用药组方规律,传承高天舒教授治疗甲亢的临床经验.方法:整理高天舒教授于2022年5月-2023年6月期间治疗甲亢的用药处方,录入中医传承辅助平台(V2.5),采用关联规则、聚类分析等统计方法对整理好的处方药物进行用药规律分析.结果:共收集处方120首,涉及中药174味,药性以寒为主,药味多为甘、苦,归经以归肝经为主.中药使用频次居前十位的依次为海藻、昆布、牡蛎、浙贝母、夏枯草、白花蛇舌草、玄参、百合、生地黄、知母.核心处方为海藻、昆布、牡蛎、浙贝母、夏枯草、白花蛇舌草,形成潜在新处方11首.结论:高天舒教授认为"阴虚火旺,痰气互结"乃甲亢根本病机,治疗以滋阴降火散结为主,灵活运用富碘中药咸寒软坚,并根据患者个人体质不同攻补兼施,从而改善患者症状,抑制甲亢.
Abstract
Objective:Based on the traditional Chinese medicine inheritance support system software(TCMISS)of version 2.5,the medication composition rules of Professor GAO Tianshu in treating hyperthyroidism was explored to inherit Professor GAO Tianshu's clinical experience in treating hyperthyroidism.Methods:Professor GAO Tianshu's medication prescriptions for treating hyperthyroidism from May 2022 to June 2023 were organized and were input into TCMISS.Statistical methods such as association rules,cluster analysis were used to analyze the medication patterns of the compiled prescription drugs.Results:A total of 120 prescriptions were collected,involving 174 traditional Chinese medicines.The medicinal properties are mainly cold,and the medicinal flavors are mostly sweet and bitter.The main meridian is liver meridian.The top ten frequently used Chinese medicines are Haizao(Sargassum),Kunbu(Thallus Laminariae Thallus Eckloniae),Muli(Concha Ostreae),Zhebeimu(Bulbus Fritillariae Thunbergii),Xiakucao(Spica Prunellae),Baihuasheshecao(Herba Hedyoti Diffusae),Xuanshen(Radix Scrophulariae),Baihe(Bulbus Lilii),Shengdihuang(Radix Rehmanniae),Zhimu(Rhizoma Anemarrhenae).The core prescriptions are composed of Haizao,Kunbu,Muli,Zhebeimu,Xiakucao and Baihuasheshecao,forming 11 potential new prescriptions.Conclusion:Professor GAO Tianshu believes that the fundamental pathogenesis of hyperthyroidism is Yin(阴)deficiency and excessive fire,with phlegm and Qi(气)intertwined.The treatment mainly focuses on nourishing Yin,reducing fire,and dispersing nodules,flexibly using iodine rich traditional Chinese medicine.According to the individual constitution of the patient,both attack and supplement were used to relieve clinical symptoms to suppress hyperthyroidism.
关键词
甲状腺功能亢进症/数据挖掘/中医传承辅助平台Key words
Hyperthyroidism/Data mining/Traditional Chinese Medicine Inheritance Support System引用本文复制引用
基金项目
辽宁省中医药临床学(专)科能力建设项目(LNZYXZK201902)
沈阳市临床医学研究中心项目(沈科发[2018]75号)
出版年
2024
国家科技期刊平台
NSTL
万方数据