A Meta-analysis of the clinical effect of the Danggui Sini decoction on CHD angina pectoris
Objective:To evaluate the clinical efficacy and safety of the Danggui Sini decoction(当归四逆汤)on coronary heart disease and angina pectoris,and to provide guidance for clinical practice.Methods:According to the preset inclusion and exclusion criteria,the two researchers searched the clinical randomized controlled trials(RCTs)of the Danggui Sini decoction for the treatment of coronary heart disease angina pectoris in the databases of CNKI,Wanfang,VIP,CBM,PubMed,Cochrane Library,EmBase from the time of establishment to January 2023,and independently extracted the basic data.The Cochrane evaluation manual handbook was used to evaluate the quality of the included literature,and Meta-analysis was performed on the extracted data by RevMan 5.4.Results:A total of 13 RCT studies were included,all of which were published in Chinese.The results showed that compared with conventional western medicine alone,the Danggui Sini decoction combined with conventional western medicine has a better clinical effect on coronary heart disease angina pectoris(RR=1.26,95％CI[1.18,1.35],P＜0.000 01).Electrocardiographic efficacy was improved(RR=1.22,95％CI[1.08,1.38],P=0.001),frequency of angina attacks was reduced(MD=-1.38,95％CI[-2.23,-0.42],P=0.005),duration of angina pectoris was shortened(MD=-1.38,95％CI[-2.34,-0.42],P=0.005),and the differences were statistically significant.Conclusion:The Danggui Sini decoction combined with conventional westem medicine on coronary heart disease can improve the overall clinical efficacy and safety.
The Danggui Sini decoctionCoronary heart diseaseAngina pectorisEfficacyMeta-analysis
NETL
NSTL
万方数据
