摘要
目的:运用数据挖掘方法分析盛梅笑教授治疗免疫球蛋白A肾病组方用药规律和治则治法.方法:收集、整理盛梅笑教授临床诊治免疫球蛋白A肾病289诊次处方,对常用中药进行频次统计,基于关联规则分析处方规律,运用复杂网络分析提取核心药物组合.结果:在289首处方中,共纳入179味中药,使用频次超过52次的中药有30种,包括石韦、黄芪、桑寄生、藤梨根、续断、白术、僵蚕、白英等,其中石韦、黄芪使用频次最高,超过75次.常用中药以甘温为主,分别占比35.46％和31.14％.补气药使用频次最高,达678次,其次为利水消肿药、清热解毒药、利尿通淋药、凉血止血药.基于关联规则分析处方规律,常用对药有续断-桑寄生、黄芪-桑寄生、黄芪-石韦,角药有黄芪-续断-桑寄生、桑寄生-石韦-续断、黄芪-石韦-桑寄生.运用复杂网络分析,设置执行度为0.98,得到3组核心处方,当节点度值为20时,得出免疫球蛋白A肾病基本方为黄芪、白术、桑寄生、续断、石韦、藤梨根、僵蚕.结论:免疫球蛋白A肾病病机特点为本虚标实,本虚以脾肾气阴两虚为主,湿热、瘀血为标,治当厘清标本,扶正、祛邪并施,益肺固表、健脾补肾培其本,兼以祛风除湿,清利活血治其标.
Abstract
Objective:To analyze the medication rule,therapeutic principle and method in the treatment of IgAN by Professor SHENG Meixiao by data mining.Methods:A total of 289 prescriptions from Professor SHENG Meixiao for treating IgAN were collected and sorted out to perform frequency of usage of commonly used Chinese medicinal materials.The prescription medication rule was analyzed based on association rules,and the core drug combination was extracted by complex network analysis.Results:A total of 179 Chinese medicinal materials were included in 289 prescriptions,and 30 Chinese medicinal materials were used more than 52 times,including Shiwei(Folium Pyrrosiae),Huangqi(Radix Astragali),Sangjisheng(Herba Taxilli),Tengligen(Rattan pear root),Xuduan(Radix Dipsaci),Baizhu(Atractylodis Macrocephalae),Jiangcan(Bombyx Batryticatus),Baiying(Solanum lyratum Thunb),etc.Among them,Shiwei and Huangqi were used the most frequently,more than 75 times.The main Chinese medicinal materials were sweet and warm medicines,accounting for 35.46％and 31.14％,respectively.Qi(气)-tonifying drugs were used most frequently,up to 678 times,followed by inducing diuresis for removing edema medicines,clearing heat and removing toxicity medicines,dispelling dampness and stranguria medicines,and cooling blood or stopping bleeding medicines.According to the analysis of prescription rules based on association rules,the commonly used mated drug combinations were Xuduan-Sangjisheng,Huangqi-Sangjisheng,and Huangqi-Shiwei,the triangular drug combinations included Huangqi-Xuduan-Sangjisheng,Sangjisheng-Shiwei-Xuduan,Huangqi-Shiwei-Sangjisheng.Using complex network analysis,the execution degree was set to 0.98,and three groups of core prescriptions were obtained.When the node degree value was 20,it was concluded that the basic prescription for IgAN was composed of Huangqi,Baizhu,Sangjisheng,Xuduan,Shiwei,Tengligen,and Jiangcan.Conclusion:The pathogenesis of IgAN is characterized by deficient root and excessive superficiality.Deficient root is mainly due to deficiency of both Qi and Yin(阴)of spleen and kidney,with damp-heat and blood stasis as the excessive superficiality.The treatment should be clarifing the superficial symptoms and root causes,strengthening the body resistance and eliminating pathogenic factors simultaneously,nourishing the lung and strengthening the body,and invigorating the spleen and tonifing the kidney to cultivate the root,accompanied by dispelling wind and dampness,and clearing dysentery and promoting blood circulation to treat the superficial symptoms.
基金项目
江苏省中医院高峰人才项目(y2021rc10)
南京中医药大学中医优势学科项目(ZYX03KF077)
国家科技期刊平台
NSTL
万方数据