Discussion on the new strategy of traditional Chinese medicine in the prevention and treatment of sepsis based on"the state and target theory-regulating inflammatory response mechanism"
The"state target cause and effect"strategy was proposed by Academician TONG Xiaolin.He combines Chinese medicine thinking with modern analytical methods such as network pharmacology,proteomics and metabolomics,thus proposing new theories of Chinese medicine in treating diseases.We analysed the dialectical strategy of"state-target cause and effect"proposed by academician TONG Xiaolin.Based on the mechanism of Chinese medicine regulating inflammatory response,the diagnostic and therapeutic methods of Chinese medicine was explored to prevent and treat sepsis,in order to enhance the clinical efficacy,so as to achieve precise treatment.Modern Chinese medicine scholars classify patients with sepsis into three states:"toxic state","stasis state"and"deficiency state".These three"states"correspond to the different stages of development of the disease and are manifested in different disease mechanisms.By identifying the disease mechanism,combining the patient's clinical manifestations,the results of modern medical examinations and the pharmacology of traditional Chinese medicine,we can determine the target formulas and medicines corresponding to the different"states",and initially establish the rules and methods of treatment,in order to achieve"disease"as the weft,"state"as the warp,accurate hit"target",so as to achieve the precision of Chinese medicine regulating state.At the same time,Chinese medicine diagnosis and treatment should capture the cause of the disease.The causes of sepsis are trauma,internal injuries,and emotions.Different causes correspond to different results.Differences in clinical symptoms are mostly manifested as differences in Qi(气)and blood,deficiencies and excesses.By grasping the changes in the Qi and blood of the patients,it is possible to anticipate the disease before it occurs and prevent it from occurring.Through the"outcone"of sepsis disease,the"cause"of the disease can be found by examining the whole process of the disease,clarifying the developmental stages of the disease,summarising the core disease mechanism and finally determining the rationale,method and prescription.It aims to provide new ideas for the combined treatment of sepsis in TCM and Western medicine.
State-target cause and effectSepsisInflammatory reaction mechanismChinese medicine for prevention and treatment
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万方数据
