An analysis of the mechanism of treating atrial fibrillation with the removing wind and reducing phlegm prescription based on network pharmacology and molecular docking
Objective:To predict the targets and signaling pathways of the removing wind and reducing phlegm prescription for the treatment of atrial fibrillation through network pharmacology,so as to further explore the potential mechanism of action on atrial fibrillation.Methods:The TCMSP was used to screen the active ingredients and predict the targets of the removing wind and reducing phlegm prescription,and the active ingredient-target network was constructed.The potential targets of atrial fibrillation were searched by OMIM,TTD and GeneCards,and the protein interaction of atrial fibrillation was obtained by STRING 11.0.The data was visualized and analyzed by CytoScape 3.9.1 to construct protein-protein interaction networks of atrial fibrillation targets.Through Venny,the predicted targets of the removing wind and reducing phlegm prescription were merged with the atrial fibrillation targets to obtain the potential targets of the removing wind and reducing phlegm prescription for the treatment of atrial fibrillation,and then the database DAVID was utilized to analyze the biofunctionality and signaling pathways of the potential targets of the removing wind and reducing phlegm prescription for the treatment of atrial fibrillation.Data visualization and analysis were carried out through Bioinformatics platform,and CytoScape 3.9.1 software was used to construct the active ingredient-potential target-signaling pathway network of the removing wind and reducing phlegm prescription for the treatment of atrial fibrillation.Results:Twenty-five potential targets were predicted for the treatment of atrial fibrillation with the removing wind and reducing phlegm prescription,which could play a role in the treatment of atrial fibrillation through the AGE-RAGE signaling pathway in the diabetic complication,relaxin signaling pathway and IL-17 signaling pathway.Conclusion:The Removing wind and reducing phlegm prescription is based on multi-components,multi-targets and multi-pathways to treat atrial fibrillation.
Atrial fibrillationThe removing wind and reducing phlegm prescriptionNetwork pharmacologyMolecular dockingMechanisms of action
NETL
NSTL
万方数据
