A network Meta-analysis of the efficacy and safety of oral Chinese patent medicine in the treatment of stable angina pectoris
Objective:To analyze the efficacy and safety of seven Chinese patent medicines(CPMs)combined with western medicine in the treatment of stable angina pectoris(SAP)by network Meta-analysis(NMA).Methods:The databases included CNKI,VIP,Wanfang,PubMed were used to retrieve literature according to the inclusion and exclusion criteria.Review Manager 5.3 and Stata 13.0 were used for data analysis.Results:A total of 70 randomized controlled trial studies involving 7 119 patients were included.① In terms of the curative effect on angina pectoris,the combination of oral CPMs preparation and western medicine(WM)was significantly better than WM alone.② In terms of electrocardiogram efficacy,except for Shexiang Tongxin Diwan(麝香通心滴丸),the efficacy of other oral CPMs plus WM regimen was significantly better than WM alone.③ In terms of reducing the frequency of angina attacks,except for the Guanxin Shutong capsules(冠心舒通胶囊)+western medicine regimen,all other oral CPM regimens showed significantly better efficacy than single western medicine regimen.④ In terms of nortening the duration of angina pectoris,the efficacy of Shexiang Baoxin Wan(麝香保心丸),the Yixinshu tablets/capsules(益心舒片/胶囊)and the Shensong Yangxin capsules(参松养心胶囊)combined with WM was significantly better than that of western medicine alone.⑤ In terms of the incidence of adverse reactions,the incidence of adverse reactions of Shexiang Baoxin Wan and the Tongxinluo capsules(通心络胶囊)combined with western medicine was significantly higher than that of the Fufang Danshen Diwan(复方丹参滴丸)+western medicine.The probability ranking of each outcome indicators showed that the scheme Shexiang Baoxin Wan+western medicine is relatively superior in terms of efficacy and safety,and is the highest clinical priority in this study.In addition,in terms of safety,the probability ranking of the Tongxinluo capsules was lower than that of western medicine,but the results of NMA showed that there was no significant difference in the incidence of adverse reactions between the Tongxinluo capsules+western medicine and western medicine alone.Conclusion:The efficacy and safety of 7 kinds of oral CPMs combined with western medicine is better than that of western medicine alone,which is worthy of clinical recommendation.Oral CPMs combined with western medicine does not significantly increase the risk of safe medication while enhancing the efficacy.
Chinese patent medicinesStable angina pectorisCoronary heart diseaseNetwork Meta-analysisSystematic review
NETL
NSTL
万方数据
