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基于Meta分析的艾灸促进创面愈合的临床评价研究

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目的:系统评价艾灸促进创面愈合的临床疗效.方法:检索The Cochrane Library、PubMed、EMBase、中国知网、万方、维普数据库中已公开发表的文献,检索时限设置为建库至2022 年 11 月,相关中文检索词为"艾灸""灸法""创面愈合""创面修复""随机对照试验",英文检索词为"moxibustion""wound healing""wound repair""RCT",由两名评价员分别独立进行文献检索、筛选及数据提取,并评价相关文献质量及偏倚风险,使用RevMan 5.4 进行数据统计及分析.结果:最终纳入相关文献 13 篇,受试者总计 841 例.结果表明,与常规治疗方式相比,艾灸干预创面可提高创面愈合总有效率[相对危险度(RR)=1.61,95%置信区间(CI)(1.35,1.92),P<0.000 01],降低创面疼痛评分[均数差(MD)=-0.82,95%CI(-1.58,-0.07),P<0.000 01],改善创面分泌物情况[MD=-0.21,95%CI(-0.34,-0.08),P<0.05],促进创面肉芽组织生长[RR=-0.35,95%CI(-0.52,-0.18),P<0.000 1],减轻创面肿胀程度[MD=-0.46,95%CI(-0.63,-0.30),P<0.000 01],有效缩短创面愈合时间[MD=-4.43,95%CI(-4.85,-4.02),P<0.000 01],加速创面愈合进程.结论:艾灸在促进创面愈合方面具有一定临床疗效,但本Meta分析尚需高质量随机对照试验(Randomized Controlled Trial,RCT)原始研究数据进一步佐证艾灸促进创面愈合的有效性和安全性.
Clinical evaluation of moxibustion promoting wound healing based on Meta-analysis
Objective:To systematically evaluate the clinical efficacy of moxibustion in promoting wound healing.Methods:Published literatures in the Cochrane Library,PubMed,EMBase,CNKI,Wanfang and VIP databases were searched,and the search time was set from the establishment of the databases to November 2022.Related Chinese search terms were"moxibus-tion""moxibustion method""wound healing""wound repair"and"randomized controlled trial",and English search terms were"moxi-bustion",""wound healing","wound repair"and"RCT".Literature retrieval,screening and data extraction were conducted independently by two evaluators,and the quality and risk of bias of relevant literatures were evaluated.Data statistics and analysis were carried out using RevMan 5.4.Results:Finally,13 relevant literatures were included,with a total of 841 subjects.The results showed that compared with conventional treatment,moxibustion intervention could improve the total effective rate of wound healing[RR=1.61,95%CI(1.35,1.92),P<0.000 01]and reduce the wound pain score[MD=-0.82,95%CI(-1.58,-0.07),P<0.000 01],improve wound secretions[MD=-0.21,95%CI(-0.34,-0.08),P<0.05],promote the growth of wound granulation tissue[RR=-0.35,95%CI(-0.52,-0.18),P<0.000 1],and reduce the degree of wound swelling[MD=-0.46,95%CI(-0.63,-0.30),P<0.000 01],effectively shorten the wound healing time[MD=-4.43,95%CI(-4.85,-4.02),P<0.000 01],and accelerate the process of wound healing.Conclusion:Moxibustion has certain clinical efficacy in promoting wound healing,but high-quality RCTs original study data are needed in this Meta-analysis to further support the effectiveness and safety of moxibustion in promoting wound healing.

MoxibustionWound healingRandomized controlled trialsMeta-analysis

吴迪、蔡增进、江琼、樊文彬、倪嘉淳

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重庆医科大学附属永川中医院,重庆,402160

重庆医科大学,重庆,400010

艾灸 创面愈合 随机对照试验 Meta分析

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(21)