首页|基于数据挖掘对甘肃省名中医常亚霖治疗肺肿瘤用药规律研究

基于数据挖掘对甘肃省名中医常亚霖治疗肺肿瘤用药规律研究

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目的:运用数据挖掘技术探索常亚霖主任医师治疗肺肿瘤的用药规律,为临床提供参考.方法:收集常亚霖医师2017年1月1日-2022年12月31日在酒泉市中医院门诊治疗肺肿瘤患者的处方,建立数据资料表.使用Excel 2019对药物频次及性味归经进行统计分析;采用SPSS Modoler 18.0软件Aprior算法对药物进行关联规则分析;运用SPSS Statistics进行聚类分析.结果:共纳入处方183首,涵盖中药133种,使用总频次3 988次.其中山茱萸、附片、干姜、炙甘草、茯苓等为治疗肺肿瘤的常用药.使用较多的前3类中药分别为补虚药、温里药、活血化瘀药.药性以温、平、微温、微寒为主;药味以甘味、辛味、苦味为最;药物归经以脾经、肝经、肺经为主.关联规则分析得出附片、炙甘草、干姜、山莱萸、茯苓、甘草、大枣几味药组成的主要关联药组.聚类分析以5为距离进行分类切割,得到3组治疗肺肿瘤的核心基础方.结论:常亚霖主任治疗肺肿瘤从脾、肺二脏入手,兼顾肝、心、肾.坚持五脏同调、痰瘀并治,而首重扶正补虚、温阳化痰的治疗原则;组方潜药上以温阳补虚药、益气化痰药、降逆止呕止咳药为主,其理法方药较具特色,值得进一步研究推广.
A study on the medication rules of Professor CHANG Yalin in the treatment of lung tumor based on data mining technology
Objective:Using data mining techniques,this study analyzes and studies the prescriptions of Chief Physician CHANG Yalin in outpatient treatment of lung cancer patients,explores and summarizes the medication rules for treating lung tumors,and provides reference and dialectical medication ideas for clinical treatment of lung tumors.Methods:The prescriptions of Professor CHANG Yalin for the treatment of lung tumor patients in the outpatient department of Jiuquan traditional Chinese medicine hospital from January 1,2017 to December 31,2022 were collected,and the data table was established after summarizing and sorting.Excel 2019 was used for statistical analysis of drug frequency and nature,taste and meridian.SPSS modeler 18.0 software aprior algorithm was used for association rule analysis of drugs,and SPSS statistics was used for cluster analysis.Results:A total of 183 prescriptions were included,covering 133 types of traditional Chinese medicine,with a total frequency of use of 3 988 times.Among them,Shanzhuyu(Cornus officinalis),Fupian(Radix Aconiti Lateralis Preparata),Ganjiang(dried ginger),Zhigancao(roasted licorice),Fulin(Poria cocos),etc.were commonly used drugs for treating lung tumors.The top three types of commonly used traditional Chinese medicine were tonifying deficiency medicine,warming internal medicine,and promoting blood circulation and removing stasis medicine.The medicinal properties were mainly warm,mild,slightly warm and slightly cold.The medicinal taste was characterized by sweetness,spiciness,and bitterness.The main meridians for medication were the spleen,liver,and lung meridians.The analysis of association rules identified the main associated drug groups consisting of Fupian,Zhigancao,Ganjiang,Shangzhuyu,Fuling,Gancao,Dazao(Fructus Jujubae).Cluster analysis was performed using 5 distances for classification and segmentation,resulting in 3 sets of core basic formulas for treating lung tumors.Conclusion:Professor CHANG Yalin treatment of lung tumors starts with the spleen and lungs,taking into account the liver,hear and kidneys.Professor CHANG adhered to the principle of five internal organs harmonizing,treating phlegm and blood stasis simultaneously,and following the treatment principle of strengthening health and tonifying deficiency,warming Yang(阳)and resolving phlegm.In terms of prescription and medication,he mainly uses drugs for warming Yang and tonifying deficiency,drugs for replenishing Qi(气)and resolving phlegm,and drugs for reducing adverse reaction,stopping emesis and relieving cough.His treatment methods and medication are more distinctive,which is worthy of further research and promotion.

Lung tumorMedication ruleData mining

郭志文、马真、向雪姣、史光伟、马天翔、曾俊媛、茹爱忠

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酒泉市中医院,甘肃 酒泉,735000

肺肿瘤 用药规律 数据挖掘

酒泉市民生科技计划项目

2023MB2028

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(22)