A Meta-analysis of treating polycystic ovary syndrome with Wuji San
Objective:To evaluate the clinical effect of Wuji San(五积散)on polycystic ovary syndrome(PCOS).Methods:The randomized controlled trials(RCT)of Wuji San in the treatment of polycystic ovary syndrome and Western medicine alone published from the establishment of the database to February 18,2023 in CNKI,PubMed,EMBASE and other databases were retrieved.Data were extracted,and Cochrane literature quality evaluation tool was used for quality evaluation.RevMan5.4 software was used for Meta-analysis.Results:A total of 11 RCT studies were included,with a total of 893 patients.The results of meta-analysis showed that the effective rate of Wuji San in the treatment of PCOS was better than that of Western medicine group[RR=1.22,95％CI(1.14,l.30),P＜0.000 01].Wuji San effectively reduced the level of luteinizing hormone[MD=-1.14,95％CI(-1.73,-0.54),Z=3.75,P=0.000 2].Wuji San decreased the testosterone levels[MD=-0.24,95％CI(-0.40,-0.08),Z=2.92,P=0.003].Wuji San decreased the fasting insulin levels[MD=-2.66,95％CI(-4.91,-0.41),Z=2.31,P=0.02].Wuji San increased the number of pregnancies[RR=1.96,95％CI(1.53,2.52),Z=5.30,P＜0.000 01].Wuji San decreased the TCM syndrome score[MD=-8.88,95％CI(-12.50,-5.26),Z=4.81,P＜0.000 01].In addition,Wuji San could not effectively increase the level of follicle-stimulating hormone.Conclusion:This study shows that the total effective rate of Wuji San in the treatment of PCOS is better than that of western medicine alone,and it can effectively reduce the levels of luteinizing hormone,testosterone and fasting insulin,increase the number of pregnancies,and improve the TCM syndromes of patients.In terms of increasing follicle-stimulating hormone level,this study does not find that Wuji San is superior to Western medicine alone.More large-scale trials are expected to investigate its potential effects in the future.
万方数据
维普
