摘要
目的:对古籍中关于查隆病的内容进行数据挖掘以寻找治疗组方,对其用药规律进行总结,挖掘其共性,为治疗该病和新药研发提供方法和数据参考.方法:在选定的古籍文献中归纳治疗查隆病的组方,用Excel建立数据库,使用Apriori建模进行关联规则分析,SPSS Statistics 25.0、SPSS modeler client进行数据挖掘分析,寻找药物之间的潜在规律.结果:通过数据挖掘分析从治疗查隆病的组方中得到川木香、肉豆蔻、沉香等共28种高频次藏药,其六味以甘、苦、辛味居多;三化味以甘化味和苦化味为主;功效分类以凉血降压药、行气止痛药、行气安神药为主;药物剂量跨度和用量较大;同时得到川木香-沉香-诃子、川木香-广枣-诃子、川木香-诃子-肉豆蔻、肉豆蔻-沉香-广枣等11组核心药对;聚类分析得到6类.结论:通过对古籍文献进行数据挖掘客观分析古籍中治疗查隆病的药对和配伍特点,为临床治疗该病提供新的理论依据和思路.
Abstract
Objective:To conduct data mining on the content of"Chalong disease"in ancient books,so as to search for treatment formulas,summarize their medication pattems,and explore their commonalities,in order to provide methods and data references for the treatment of the disease and new drug research and development.Methods:The prescriptions for treating"Chalong disease"in ancient literature was selected to establish a database using Excel for association rule analysis by apriori modeling.SPSS Statistics 25.0,SPSS modeler client for data mining analysis were performed to search for potential pattems between drugs.Results:According to the data mining analysis,28 kinds of commonly used Tibetan medicines were obtained,including Chuan Muxiang(Radix Vladimiriae),Rou Doukou(Semen Myristicae)and Chenxiang(Lignum Aquilariae Resinatum).Its six flavors were mostly sweet,bitter and pungency;Sanhua tastes were mainly sweet-transform taste and bitter pransform taste.According to the classification of efficacy,Chinese medicines used were mainly the cooling blood to lower blood pressure medicine,the promoting Qi to relieve pain medicine,and the promoting Qi to calm nerves medicine.The span of doses and the amount of medicines used were large.At the same time,11 core drug pairs were obtained,such as Chuan Muxiang-Chenxiang-Hezi(Fructus Chebulae),Chuan Muxiang-Guangzao(Fructus Choerospondiatis)-Hezi,Chuan Muxiang-Hezi-Rou Doukou,Rou Doukou-Chenxiang-Guangzao.Cluster analysis obtained 6 categories.Conclusion:Through data mining of prescriptions in ancient books,the characteristics of drug pairs and compatibility in treating Chalong disease in ancient books are objectively analyzed,so as to provide new theoretical basis and ideas for the clinical treatment of this disease.
维普
万方数据