An analysis of medication rules of traditional Chinese medicine on chronic prostatitis based on data mining
Objective:The objective of this study is to analyze the medication rules of traditional Chinese medicine in the clinical research literature on chronic prostatitis in the past two decades.Methods:From February 2002 to February 2022,the relevant literature on the treatment of chronic prostatitis in traditional Chinese medicine was searched in Wanfang Data,CNKI,VIP.According to the inclusion and exclusion criteria,the prescriptions of traditional Chinese medicine for the treatment of chronic prostatitis were screened.The Microsoft Excel 2021 MSO software was used to establish a database of prescriptions for the treatment of chronic prostatitis,and the Weka 3.8 software and IBM SPSS Statistics 23 software were used to analyze the correlation rules and visualize the centrality of traditional Chinese medicines on the Window operation platform.Results:A total of 227 prescriptions and 217 flavors of traditional Chinese medicine were included.There were 28 flavors of traditional Chinese medicine with a frequency of not ess chan 30 times,of which the top 5 drugs with the highest frequency of medication were Danshen(Radix et Rhizoma Salviae Miltiorrhizae),Huangbo(Cortex Phellodendri Chinsis),Niuxi(Radix Achyranthis Bidentatae),Gancao(Radix Glycyrrhizae),and Wang-buliuxing(Semen Vaccariae).The tastes of traditional Chinese medicine used in the treatment of chronic prostatitis were mainly bitter and cold.Channel tropism mostly belonged to the liver meridian,kidney meridian,stomach meridian.According to the classification of drug efficacy,the drugs used were mainly blood activating stasis drugs,antipyretic drugs,and water infiltration drugs.The association rule analysis yielded 20 drug combinations,and the drug combinations with the highest confidence were"Shichangpu(Rhizoma Acori Tatarinowiis)→Bixie(Rhizoma Dioscoreae Septemlobae)""Honghua(Flos Carthami)→Taoren(Semen Persicae)","Zelan(Herba Lycopi)→ Danshen(Radix et Rhizoma Salviae Miltiorrhizae)".Cluster analysis yielded 3 core drug combinations.Conclusion:The treatment of chronic prostatitis in traditional Chinese medicine mainly focuses on clearing heat and dampness,and activating blood circulation and removing blood stasis,and takes tonifying kidney and warming Yang(阳),and soothing liver and regulating Qi(气)as auxiliary treatment measures.The drug combinations mined in this study are consistent with the characteristics of its pathogenesis,and have certain reference value for the combination of prescriptions and drugs and the development of new drugs for the treatment of chronic prostatitis.
Chronic prostatitisSeminal turbidityTraditional Chinese medicine treatmentData mining
万方数据
维普
