A Meta-analysis of the efficacy and safety of acupuncture combined with TCM decoction in the treatment of stroke-associated pneumonia
Objective:To evaluate the efficacy and safety of traditional Chinese medicine acupuncture combined with traditional Chinese medicine decoction in the treatment of stroke associated pneumonia using Meta-analysis systematically.Methods:Randomized controlled trials of TCM acupuncture combined with TCM decoction in the treatment of stroke-associated pneumonia were searched from CNKI,Wanfang,VIP,Web of Science,Cochrane Library and PubMed databases.The included literature was analyzed for risk of bias according to the Cochrane Manual of Systematic Reviews,Meta-analysis and graphing were made by RevMan 5.4.Results:After screening,8 studies were finally included,including a total of 590 patients,with 318 cases in the experimental group(acupuncture combined with Chinese herbal decoction)and 272 cases in the control group(conventional treatment with Western medicine).The results of Meta-analysis showed that the experimental group had better total effective rates than the control group(OR=3.28,95％CI[2.03,5.30],Z=4.86,P＜0.000 01).The results of subgroup analysis showed that the experimental group could reduce inflammatory cytokines(MD=-2.44,95％CI[-2.84,-2.03],Z=11.8,P＜0.000 1).Improve cellular immune function(MD=2.20,95％CI[1.05,3.35],Z=3.74,P＜0.000 2);The TCM syndrome score was reduced(MD=-8.19,95％CI[-14.57,-1.80],Z=2.51,P＜0.01).CPIS score was reduced(MD=-0.93,95％CI(-1.71,-0.16),Z=2.37,P＜0.02);In terms of the improvement time of symptoms and signs,there was no data to prove that the treatment effect in the experimental group was significantly better than the control group.In terms of safety:Meta data analysis on the incidence of adverse reactions and recurrence of lung infections showed that the adverse reactions and recurrence of lung infections caused by TCM acupuncture combined with TCM decoction were only comparable or reduced to those caused by conventional Western medicine treatment.Conclusion:The treatment method of acupuncture combined with TCM decoction can reduce the level of serum inflammatory factors,improve lung function,reduce the degree of lung infection,improve the clinical efficacy of stroke-associated pneumonia,and further relieve the clinical symptoms of patients.
万方数据
维普
