Exploration on the medication rules of TCM in the treatment of coronary heart disease with bradyarrhythmia based on data mining
Objective:To explore the medication rules of traditional Chinese medicine in the treatment of coronary heart disease complicated with bradyarrhythmia.Methods:By searching five databases,including CNKI and Wanfang Database,literature on traditional Chinese medicine compound therapy in the treatment of coronary heart disease with bradyarrhythmia was collected from the establishment of the database to January 10,2024.According to the inclusion and exclusion criteria,a prescription database was established,and Traditional Chinese Medicine Inheritance Support System V2.5 was used to analyze the drug frequency,medical efficacy,association rules,complex network,entropy clustering,etc.Results:A total of 43 prescriptions were included,involving 91 traditional Chinese medicinals,and the top 5 most frequently used medicinals were Danshen(Salviae Miltiorrhizae Radix et Rhizoma),Guizhi(Cinnamomi Ramulus),Huangqi(Astragali Radix),Fuzi(Radix Aconiti Lateralis Preparata)and Maidong(Radix Ophiopogom).The most frequently classified Chinese medicinals were tonifying drugs,which were followed by blood-activating and stasis-resolving drugs,exterior relieving drugs,interior warming drugs and Qi(气)-regulating drugs.The four properties were mainly warm,cold and mild.The five flavors were mainly sweet,pungent,and bitter.The main channel tropism included the heart meridian,lung meridian,spleen meridian,liver meridian,and kidney meridian in order.The commonly used medicinal pairs were Danshen-Guizhi,Chuanxiong(Rhizoma Chuanxiong)-Danshen,Huangqi-Guizhi,and Danshen-Fuzi.The following four groups of new prescriptions were obtained by clustering:Wuweizi(Fructus Schisandrae Chinensis)-Fuzi-Mahuang(Herba Ephedrae)-Maidong-Huomaren(Fructus Cannabis),Rougui(Cortex Cinnamomi)-Gualou(Fructus Trichosanthis)-Baizhu(Atractylode)-Tusizi(Semen Cuscutae),Danshen-Fuling(Poria)-Chenpi(Pericarpium Citri Reticulatae)-Maidong,and Chuanxiong-Honghua(Flos Carthami)-Xiebai(Bulbus Allii Macrostemonis)-Guolou-Baizhu.Conclusion:The basic pathogenesis of coronary heart disease with bradyarrhythmia is deficiency in origin and excess in superficiality,and the deficiency syndrome is mostly Qi deficiency and Yang(阳)deficiency,the excess syndrome is mostly blood stasis,and cold coagulation.The compatibility of TCM treatment is mainly based on supplementing Qi and promoting blood circulation,accompanied by warming Yang and dredging collaterals,regulating Qi and eliminating phlegm,and nourishing blood and Yin based on syndrome differentiation,which can provide a certain reference for the clinical medication.
Coronary heart disease with bradyarrhythmiaMedication ruleData mining
万方数据
维普
