Effects of Zhuangtong Yin on serum inflammatory factors in patients with unstable angina pectoris blood stasis syndrome of coronary heart disease
Objective:To study the curative effect of Zhuangtong Yin(壮通饮)on unstable angina pectoris and its effect on serum inflammatory factors.Methods:A total of 109 patients with unstable angina pectoris blood stasis syndrome of coronary heart disease were randomly divided into the observation group(55 cases)and the control group(54 cases).The observation group was given basic Western medicine treatment plus Zhuangtong Yin treatment,and the control group was given basic Western medicine treatment for 2 weeks.The clinical efficacy,the changes of blood stasis scores,and the changes of serum C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)were observed before and after treatment.Results:①T Zhuangtong Yin was effective in the treatment of unstable angina pectoris of coronary heart disease,and it can relieve the clinical symptoms and decrease blood stasis scores,which had statistical significance compared with those in the control group(P＜0.01).② After the control group received basic Western medicine treatment,CRP had no significant change,which was not statistically significant compared with that before treatment(P＞0.05),and TNF-α was significantly increased,which was statistically significant compared with that before treatment(P＜0.01).in the observation group,after basic Western medicine treatment plus Zhuangtong Yin treatment,CRP was significantly decreased,which was statistically significant compared with that before treatment(P＜0.05),and TNF-α was significantly increased,which was statistically significant compared with that before treatment(P＜0.01).③ Comparison was made between the observation group and the control group after treatment:Zhuangtong Yin could regulate the expression of serum inflammatory factors,CRP was significantly decreased(P＜0.05),and TNF-α was significantly increased(P＜0.01),and the comparison between the two groups after treatment had statistical significance(P＜0.05).Conclusion:Zhuangtong Yin is effective in treating unstable angina pectoris blood stasis syndrome of coronary heart dis-ease.It can relieve the clinical symptoms and decrease blood stasis syndrome score of patients,further inhibit the expression level of inflammatory factor CRP,increase the expression level of TNF-α,inhibit inflammatory response,and play a role in the treatment of unstable angina pectoris of coronary heart disease from the pathophysiological aspect,which is worthy of clinical promotion.
万方数据
维普
