Clinical study on the effect of Shaofu Zhuyu decoction retention enema combined with antibiotics on chronic endometritis of the cold-dampness stagnation type
Objective:To observe the clinical effect of Shaofu Zhuyu decoction(少腹逐瘀汤)retention enema combined with antibiotics on chronic endometritis of the cold-dampness stagnation type.Methods:A total of 90 patients with chronic endometritis of the cold-dampness stagnation type after hysteroscopy were selected and divided randomly into the control group and the observation group,with 45 cases in each group.Both groups were treated with doxycycline orally for 14 days,and the observation group was additionally treated with Shaofu Zhuyu decoction retention enema.Hysteroscopy and endometrial immunohistochemistry were performed 3 to 7 days after the first menstrual period after treatment.The clinical efficacy,TCM syndrome score before and after treatment,the positive detection rate of CD38 and CD 138 in immunohistochemistry and the incidence of adverse events during treatment were compared between the two groups.Results:The total effective rate in the observation group was 97.8％(44/45),which was higher than that in the control group,82.2％(37/45),and the difference was statistically significant(P＜0.05).After treatment,the scores of TCM syndromes of lower abdominal pain,abnormal menstruation and profuse vaginal discharge in both groups were significantly lower than those before treatment(P＜0.01),and in the observation group was significantly lower than the control group(P＜0.05).The positive rates of immunohistochemical CD38 and CD 138 in 2 groups were significantly lower than those before treatment(P＜0.01),and in the observation group was significantly lower than the control group(P＜0.05).There was no significant difference in the incidence of adverse events between two groups during treatment(P＞0.05).Conclusion:Shaofu Zhuyu decoction retention enema combined with antibiotics has definite efficacy in the treatment of chronic endometritis of the cold-dampness stagnation type,which can effectively ameliorate the TCM syndromes of patients,and reduce plasma cell infiltration,and it has good safety.
万方数据
维普
