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从《读医随笔》升降出入论浅析肺间质纤维化

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肺间质纤维化是一种慢性弥漫性间质性肺疾病,以肺成纤维细胞和肌成纤维细胞的异常增殖及细胞外基质蛋白的过度沉积和异常调节为特征,可导致患者气体交换受损、呼吸困难、生活质量下降甚至因呼吸衰竭而死亡,发病机制复杂.根据发病的临床特点,中医学将肺间质纤维化归于"肺痹""肺痿"范畴.研究基于中医玄府理论、脏腑理论,从清代名医周学海《读医随笔》升降出入理论入手,梳理肺间质纤维化的中医辨治思路,归纳肺间质纤维化的基本病机为本虚标实,以肺气虚为本,痰瘀互结为标.久病气耗,虚热内生,影响气机的升降出入,导致痰浊瘀血产生.笔者探讨肺间质纤维化与人体气机升降出入的关系,认为调理人体气机有利于缓解肺间质纤维化症状,并从开通玄府、疏肝理肺、补养脾胃、祛痰化瘀等方面论治,以期从中医学观点探析肺间质纤维化的诊治.
A brief analysis of pulmonary interstitial fibrosis from the ascending,descending,exiting and entering theory in Duyi Suibi
Pulmonary interstitial fibrosis(IPF)is a chronic diffuse interstitial lung disease characterized by lung fibroblasts and muscle fibroblasts abnormal proliferation,and extracellular matrix proteins excessive deposition and abnormal regulation,which can lead to impaired gas exchange,dyspnea,decreased quality of life and even death due to respiratory failure of patients.Its pathogenesis is complex.According to the clinical characteristics,IPF belongs to the categories of lung palsy and lung flaccidity in traditional Chinese medicine.Based on the Xuanfu(玄 府)theory and Zang-fu viscera(脏腑)theory in TCM,this paper began with the ascending,descending,exiting and entering theory in Duyi Suibi(《读医随笔》)by ZHOU Xuehai,a famous TCM practitioner in the Qing Dynasty,and summarized the basic pathogenesis of IPF as deficiency in origin and excess in superficiality,taking lung Qi(气)deficiency as the foundation and phlegm and blood stasis coagulation as exterior symptoms.After a long illness,Qi is comsumed,and heat is endogenous,which affects the ascending,descending,exiting,and entering of Qi movement,leading to the production of phlegm and blood stasis.The author discusses the relationship between IPF and the ascending,descending,exiting and entering of Qi movement of human body,and believes that the adjustment of Qi movement of human body is beneficial to alleviate the symptoms of IPF,and discusses the treatment from the aspects of opening Xuanfu,soothing liver and regulating lung,nourishing spleen and stomach,and dispelling phlegm and removing blood stasis,in order to analyze the diagnosis and treatment of IPF in TCM.

Duyi SuibiAscending,descending,exiting and enteringPulmonary interstitial fibrosis

袁欣悦、史依依、苏洁琼、白丽、郭偏偏

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山西中医药大学,山西 太原,030024

山西中医药大学附属中西医结合医院,山西 太原,030013

《读医随笔》 升降出入 肺间质纤维化

2024

中医临床研究
中华中医药学会

中医临床研究

影响因子:0.839
ISSN:1674-7860
年,卷(期):2024.16(25)