Research progress of saponins in reducing toxicity of chemotherapeutic drugs
Chemotherapy medicines are one of the main means to treat malignant tumors.However,toxic side effects and drug resistance are the key reasons to limit its efficacy.Traditional Chinese medicine has the characteristics of multi-molecule and multi-target,and is an important part of complementary and alternative medicine.It can not only prevent the occurrence and development of tumors,improve the efficacy of western medicine,but also alleviate the toxic and side effects of western medicine.Saponin components in traditional Chinese medicine are a complex glycoside compound with the advantages of rich source,high safety and small side effects.Saponins are important active ingredients of traditional Chinese medicine,which have a wide range of biological activities such as antitumor,anti-oxidation and regulating immunity.In recent years,many studies have shown that TCM saponins can effectively reduce the side effects of chemotherapeutic medicines.This paper summarizes the adverse reactions of chemotherapeutic medicines,the attenuation effect of saponins on chemotherapeutic medicines,and the attenuation effect of saponins on normal tissues and organs,expounds the research progress of combined traditional Chinese and Western medicine to reduce the toxicity of chemotherapeutic medicines,and puts forward a new way.This paper is expected to provide a theoretical basis for the study of saponins in traditional Chinese medicine and its combination with chemotherapeutic drugs,and provide support for the development of new medicines.
Traditional Chinese medicineSaponinsChemotherapeutic medicinesAattenuation virulenceResearch progress
万方数据
维普
